Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	YY1
Symbol Alias	NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S
Approved Name	YY1 transcription factor
Name Alias	INO80 complex subunit S, "Yin and Yang 1 protein"
Location	14q
Position	chr14:100238298-100282792, 1
External Links	HGNC: 12856 Entrez Gene: 7528 Ensembl: ENSG00000100811 UCSC: uc001ygy.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs1951521	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 33)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030154	cell differentiation	biological process	IEA	31
GO:0003714	transcription corepressor activity	molecular function	TAS[1655281]	21
GO:0005634	nucleus	cellular component	IDA[18026119]; IMP[22065573]	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	TAS[1946405]	66
GO:0003677	DNA binding	molecular function	IDA[21729784]	83

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[9857059]	62
GO:0031519	PcG protein complex	cellular component	IEA	2
GO:0031011	Ino80 complex	cellular component	IDA[18026119]	3
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	ISS	14
GO:0001158	enhancer sequence-specific DNA binding	molecular function	IMP[15329343]	3
GO:0016363	nuclear matrix	cellular component	IEA	7
GO:0000400	four-way junction DNA binding	molecular function	IDA[18026119]	2
GO:0048593	camera-type eye morphogenesis	biological process	IEA	3
GO:0051276	chromosome organization	biological process	IEA	2
GO:0010628	positive regulation of gene expression	biological process	IEA	23
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0034696	response to prostaglandin F	biological process	IEA	1
GO:0005667	transcription factor complex	cellular component	IEA	18
GO:0009952	anterior/posterior pattern specification	biological process	IEA	6
GO:0000724	double-strand break repair via homologous recombination	biological process	IMP[18026119]	9
GO:0005515	protein binding	molecular function	IPI[10369680]	563
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[1655281]	21
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[9857059]	17
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0008270	zinc ion binding	molecular function	TAS[1655281]	77
GO:0046332	SMAD binding	molecular function	IMP[15329343]	2
GO:0003713	transcription coactivator activity	molecular function	TAS[1946405]	22
GO:0010629	negative regulation of gene expression	biological process	IMP[22065573]	12
GO:0010225	response to UV-C	biological process	IMP[18026119]	2
GO:0034644	cellular response to UV	biological process	IMP[18026119]	5
GO:0003723	RNA binding	molecular function	IDA[21729784]	14
GO:0006403	RNA localization	biological process	IEA	1
GO:0006974	cellular response to DNA damage stimulus	biological process	IMP[18026119]	14

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 19)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
YY1	FKBP3	NO	in vitro;in vivo	11532945
YY1	EP300	NO	in vivo	7758944
YY1	SAP30	NO	in vitro;in vivo;yeast 2-hybrid	12788099
YY1	HDAC3	NO	in vitro	9346952
YY1	FKBP1A	NO	yeast 2-hybrid	7541038
YY1	E2F2	NO	in vitro;in vivo;yeast 2-hybrid	12411495
YY1	ATF6	NO	in vivo	10866666
YY1	RYBP	NO	in vitro;in vivo	10369680
YY1	E2F3	NO	in vitro;in vivo;yeast 2-hybrid	12411495
YY1	MYC	NO	in vitro;yeast 2-hybrid	8266081
YY1	ZRANB2	NO	in vivo	11448987
YY1	SREBF1	NO	in vitro	10224053
YY1	SP1	NO	in vitro;in vivo	9278494
YY1	BRCA1	NO	in vitro	11777930
YY1	YAF2	NO	in vitro;yeast 2-hybrid	9016636
YY1	NOTCH1	NO	in vitro;in vivo	12913000
YY1	GTF2I	NO	in vitro;in vivo	11287625
YY1	HDAC2	NO	in vitro;in vivo	11486036
YY1	EED	NO	in vitro;in vivo	11158321

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1951521	chr14:100277084 - 100277084(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr14:100238298..100282792 View in gBrowse