Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	YY1
Symbol Alias	NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S
Approved Name	YY1 transcription factor
Name Alias	INO80 complex subunit S, "Yin and Yang 1 protein"
Location	14q
Position	chr14:100238298-100282792, 1
External Links	HGNC: 12856 Entrez Gene: 7528 Ensembl: ENSG00000100811 UCSC: uc001ygy.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs1951521	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 33)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030154	cell differentiation	biological process	IEA	31
GO:0003714	transcription corepressor activity	molecular function	TAS[1655281]	21
GO:0005634	nucleus	cellular component	IDA[18026119]; IMP[22065573]	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	TAS[1946405]	66
GO:0003677	DNA binding	molecular function	IDA[21729784]	83

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[9857059]	62
GO:0031519	PcG protein complex	cellular component	IEA	2
GO:0031011	Ino80 complex	cellular component	IDA[18026119]	3
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	ISS	14
GO:0001158	enhancer sequence-specific DNA binding	molecular function	IMP[15329343]	3
GO:0016363	nuclear matrix	cellular component	IEA	7
GO:0000400	four-way junction DNA binding	molecular function	IDA[18026119]	2
GO:0048593	camera-type eye morphogenesis	biological process	IEA	3
GO:0051276	chromosome organization	biological process	IEA	2
GO:0010628	positive regulation of gene expression	biological process	IEA	23
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0034696	response to prostaglandin F	biological process	IEA	1
GO:0005667	transcription factor complex	cellular component	IEA	18
GO:0009952	anterior/posterior pattern specification	biological process	IEA	6
GO:0000724	double-strand break repair via homologous recombination	biological process	IMP[18026119]	9
GO:0005515	protein binding	molecular function	IPI[10369680]	563
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[1655281]	21
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[9857059]	17
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0008270	zinc ion binding	molecular function	TAS[1655281]	77
GO:0046332	SMAD binding	molecular function	IMP[15329343]	2
GO:0003713	transcription coactivator activity	molecular function	TAS[1946405]	22
GO:0010629	negative regulation of gene expression	biological process	IMP[22065573]	12
GO:0010225	response to UV-C	biological process	IMP[18026119]	2
GO:0034644	cellular response to UV	biological process	IMP[18026119]	5
GO:0003723	RNA binding	molecular function	IDA[21729784]	14
GO:0006403	RNA localization	biological process	IEA	1
GO:0006974	cellular response to DNA damage stimulus	biological process	IMP[18026119]	14

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 19)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
YY1	ZRANB2	NO	in vivo	11448987
YY1	SAP30	NO	in vitro;in vivo;yeast 2-hybrid	12788099
YY1	GTF2I	NO	in vitro;in vivo	11287625
YY1	HDAC2	NO	in vitro;in vivo	11486036
YY1	E2F2	NO	in vitro;in vivo;yeast 2-hybrid	12411495
YY1	FKBP1A	NO	yeast 2-hybrid	7541038
YY1	MYC	NO	in vitro;yeast 2-hybrid	8266081
YY1	ATF6	NO	in vivo	10866666
YY1	EED	NO	in vitro;in vivo	11158321
YY1	NOTCH1	NO	in vitro;in vivo	12913000
YY1	BRCA1	NO	in vitro	11777930
YY1	YAF2	NO	in vitro;yeast 2-hybrid	9016636
YY1	SREBF1	NO	in vitro	10224053
YY1	E2F3	NO	in vitro;in vivo;yeast 2-hybrid	12411495
YY1	EP300	NO	in vivo	7758944
YY1	HDAC3	NO	in vitro	9346952
YY1	FKBP3	NO	in vitro;in vivo	11532945
YY1	SP1	NO	in vitro;in vivo	9278494
YY1	RYBP	NO	in vitro;in vivo	10369680

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1951521	chr14:100277084 - 100277084(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:100238298..100282792 View in gBrowse