Gene Report

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Basic Info

Approved Symbol	POU3F2
Previous Symbol	OTF7
Symbol Alias	POUF3, BRN2, OCT7
Approved Name	POU class 3 homeobox 2
Previous Name	POU domain class 3, transcription factor 2
Location	6q16.2
Position	chr6:98834592-98839470, 1
External Links	HGNC: 9215 Entrez Gene: 5454 Ensembl: ENSG00000184486 UCSC: uc003ppe.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Muhleisen, T. W., 2014	SNP: rs12202969	As the fourth most significant finding in our study	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043565	sequence-specific DNA binding	molecular function	IEA	29
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042802	identical protein binding	molecular function	IPI[11029584]	44
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	91
GO:0071310	cellular response to organic substance	biological process	IEA	5
GO:0021799	cerebral cortex radially oriented cell migration	biological process	IEA	5
GO:0050770	regulation of axonogenesis	biological process	IEA	7
GO:0021869	forebrain ventricular zone progenitor cell division	biological process	IEA	1
GO:0022011	myelination in peripheral nervous system	biological process	IEA	2
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0014002	astrocyte development	biological process	IEA	3
GO:0021985	neurohypophysis development	biological process	IEA	1
GO:0008284	positive regulation of cell proliferation	biological process	IDA[15024079]	44
GO:0040018	positive regulation of multicellular organism growth	biological process	IEA	8
GO:0005515	protein binding	molecular function	IPI[11029584]	563
GO:0021979	hypothalamus cell differentiation	biological process	IEA	1
GO:0008544	epidermis development	biological process	IEA	7
GO:0030182	neuron differentiation	biological process	IEA	5
GO:0005667	transcription factor complex	cellular component	IEA	18
GO:0001105	RNA polymerase II transcription coactivator activity	molecular function	IEA	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
POU3F2	EP300	NO	in vitro;yeast 2-hybrid	11029584
POU3F2	SOX10	NO	in vitro;yeast 2-hybrid	11029584
POU3F2	GTF2B	NO	in vitro	11029584
POU3F2	POU3F4	NO	in vitro	9105675
POU3F2	SOX11	NO	in vitro	9632656
POU3F2	PQBP1	NO	in vitro;in vivo;yeast 2-hybrid	10332029
POU3F2	TBP	YES	in vitro;yeast 2-hybrid	11029584

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs12202969	chr6:98128347 - 98128347(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q16.1	chr6:92500000-98900000	1 (0/1/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q16	chr6:92500000-105000000	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:98834592..98839470 View in gBrowse