Gene Report

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Basic Info

Approved Symbol	TACC3
Symbol Alias	ERIC1
Approved Name	transforming, acidic coiled-coil containing protein 3
Location	4p16.3
Position	chr4:1721490-1745176, 1
External Links	HGNC: 11524 Entrez Gene: 10460 Ensembl: ENSG00000013810 UCSC: uc003gdo.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.14. Encodes for a member of the transforming acidic colied-coil protein family. It is involved in the microtubule-dependent coupling of the nucleus and the centrosome and regulates centrosome-mediated inter kinetic nuclear migration (INM) of neural progenitors.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019904	protein domain specific binding	molecular function	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030097	hemopoiesis	biological process	IEA	7
GO:0032886	regulation of microtubule-based process	biological process	IEA	4
GO:0022027	interkinetic nuclear migration	biological process	IEA	2
GO:0001666	response to hypoxia	biological process	IEA	24
GO:0008283	cell proliferation	biological process	IBA	37
GO:0005813	centrosome	cellular component	IDA	34
GO:0005515	protein binding	molecular function	IPI[20360068]	563
GO:0000226	microtubule cytoskeleton organization	biological process	IBA	9
GO:0022008	neurogenesis	biological process	IEA	4
GO:0051726	regulation of cell cycle	biological process	IEA	6
GO:0021987	cerebral cortex development	biological process	IBA	9
GO:0042994	cytoplasmic sequestering of transcription factor	biological process	IEA	2
GO:0030953	astral microtubule organization	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TACC3	KAT2A	NO	in vitro	14767476
TACC3	TTF2	NO	yeast 2-hybrid	12927788
TACC3	AURKA	NO	in vitro;yeast 2-hybrid	14602875
TACC3	AKAP9	NO	yeast 2-hybrid	12015314

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
4p16.3	chr4:0-4500000	1 (1/0/0)
Chr 4	chr4:0-190214555	3 (0/3/0)
4p16	chr4:0-11300000	2 (0/1/1)
4p	chr4:0-50000000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:1721490..1745176 View in gBrowse