Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PRLR
Approved Name	prolactin receptor
Location	5p14-p13
Position	chr5:35048756-35230589, -1
External Links	HGNC: 9446 Entrez Gene: 5618 Ensembl: ENSG00000113494 UCSC: uc032uqm.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs7720677	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 26)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IEA	219

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042110	T cell activation	biological process	NAS[10585417]	9
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	biological process	IDA[10585417]	5
GO:0030155	regulation of cell adhesion	biological process	IEA	3
GO:0031904	endosome lumen	cellular component	TAS	3
GO:0006694	steroid biosynthetic process	biological process	NAS[10585417]	2
GO:0005576	extracellular region	cellular component	IEA	97
GO:0005515	protein binding	molecular function	IPI[23048206]	563
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	biological process	TAS	1
GO:0060644	mammary gland epithelial cell differentiation	biological process	IEA	3
GO:0060749	mammary gland alveolus development	biological process	IEA	4
GO:0007566	embryo implantation	biological process	TAS[9009200]	8
GO:0017046	peptide hormone binding	molecular function	IPI[7984244]	4
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0030856	regulation of epithelial cell differentiation	biological process	IEA	1
GO:0060736	prostate gland growth	biological process	IEA	2
GO:0042803	protein homodimerization activity	molecular function	NAS[10585417]	71
GO:0007595	lactation	biological process	NAS[10585417]	5
GO:0038161	prolactin signaling pathway	biological process	IEA	1
GO:0007166	cell surface receptor signaling pathway	biological process	NAS[10585417]	23
GO:0043066	negative regulation of apoptotic process	biological process	NAS[10585417]	46
GO:0042978	ornithine decarboxylase activator activity	molecular function	NAS[10585417]	1
GO:0004925	prolactin receptor activity	molecular function	NAS[10585417]	1
GO:0009986	cell surface	cellular component	IDA[10585417]	40
GO:0042977	activation of JAK2 kinase activity	biological process	NAS[10585417]	1

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa04080	Neuroactive ligand-receptor interaction	92
hsa04060	Cytokine-cytokine receptor interaction	17
hsa04630	Jak-STAT signaling pathway	14

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 16)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PRLR	PPIA	NO	in vitro;in vivo	12668872
PRLR	VAV2	NO	in vivo	15618286
PRLR	SOCS3	NO	in vivo	11713228
PRLR	JAK2	NO	in vivo	10772872
PRLR	TEC	NO	in vitro;in vivo	11328862
PRLR	SOCS2	NO	in vitro;in vivo	10455112 , 9202403
PRLR	GH1	NO	in vitro	9556914
PRLR	CISH	NO	in vivo	11713228
PRLR	NEK3	NO	in vivo	15618286
PRLR	YWHAZ	NO	in vitro;in vivo	12819209
PRLR	PRL	NO	in vitro;in vivo	9626554 , 10966654 , 7984244
PRLR	CSH1	NO	in vitro	10966654
PRLR	PTPN11	NO	in vitro	10991949 , 14522994
PRLR	VAV1	NO	in vivo	7768923
PRLR	YWHAG	NO	in vitro;in vivo	12819209
PRLR	ZAP70	NO	in vitro	10221598

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7720677	chr5:35240099 - 35240099(1)		1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5p13.3-q13.3	chr5:28900000-77600000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:35048756..35230589 View in gBrowse