Gene Report

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Basic Info

Approved Symbol	PNOC
Symbol Alias	PPNOC
Approved Name	prepronociceptin
Name Alias	nocistatin
Location	8p21
Position	chr8:28316986-28343355, 1
External Links	HGNC: 9163 Entrez Gene: 5368 Ensembl: ENSG00000168081 UCSC: uc003xgp.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		7 SNP typed, Median D'=1, Median r<sup>2</sup> =0.09, 1 LD blocks, 0.67 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	IEA	116

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005184	neuropeptide hormone activity	molecular function	TAS[10419552]	8
GO:0005515	protein binding	molecular function	IPI[23597562]	563
GO:0005576	extracellular region	cellular component	TAS	97
GO:0001515	opioid peptide activity	molecular function	IEA	2
GO:0007218	neuropeptide signaling pathway	biological process	IEA	18
GO:0007165	signal transduction	biological process	TAS[9521323]	136
GO:0007600	sensory perception	biological process	TAS[9521323]	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PNOC	OPRL1	NO	in vitro;in vivo	10692489 , 11097863

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p21	chr8:19200000-29000000	2 (0/1/1)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend

Gene relationship with MDD

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Region: chr8:28316986..28343355 View in gBrowse