Gene Report

Approved Symbol	ANK3
Approved Name	ankyrin 3, node of Ranvier (ankyrin G)
Name Alias	ankyrin-3, node of Ranvier, "ankyrin-G"
Location	10q21
Position	chr10:60026298-60733490, -1
External Links	HGNC: 494 Entrez Gene: 288 Ensembl: ENSG00000151150 UCSC: uc001jky.3
No. of Studies	17 (Positive: 13; Negative: 3; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fiorentino A., 2014	SNP: rs78682113, rs114693358, rs72816484, rs11816586, rs12257876, rs1050745, rs79598579, rs190133850, rs12265962, rs7078873, rs74155257, rs8677, rs187326819, rs1802665, rs199763470, rs80034950, rs1049862, rs188594839, rs181062313, rs149282429, rs141939315, rs139092048, rs147527383, rs61845768, rs140183285, rs10821668, rs28932171, rs41274672, rs11599164, rs139972937, rs148904927, rs117475706, rs2393595, rs6479694, rs16914794, rs181454508, rs117421224, rs41283526, rs34796699, rs77622274, rs1551684, rs1551683, rs139578151, rs7903279, rs1442547, rs1442548, rs74659950, rs151007800, rs112339619, rs184389434, rs1904397, rs1904398, rs144130033 Other variant: ANK3_Chr10:61786761 _A/G, ANK3_Chr10:61787065 _TA/-, ANK3_Chr10:61788626 _G/T, ANK3_Chr10:61789498 _AC/-, ANK3_Chr10:61789512 _C/-, ANK3_Chr10:61789556 _C/-, ANK3_Chr10:61819783 _T/G, ANK3_Chr10:61841574 _T/-, ANK3_Chr10:61843365 _C/G, ANK3_Chr10:61900256 _G/A, ANK3_Chr10:61900727 _G/C, ANK3_Chr10:61900857 _G/A, ANK3_Chr10:61901317 _-/TG, ANK3_Chr10:61901321 _T/G, ANK3_Chr10:61941143 _C/G, ANK3_Chr10:61958307 _G/T, ANK3_Chr10:62149642 _C/T, ANK3_Chr10:62150190 _G/A, ANK3_Chr10:62332894 _-/A, ANK3_Chr10:62332895 _A/AA, ANK3_Chr10:62332985 _T/-, ANK3_Chr10:62333120 _ACCAACCA/-, ANK3_Chr10:62493812 _G/C, ANK3_Chr10:62494029 _A/G, ANK3_Chr10:62494113 _C/T, ANK3_Chr10:62494201 _CT/CTATATTAT, rs3045444	Genetic markers in the genes encoding ankyrin 3 (ANK3) is associated with bipolar disorder (BP).	Positive	Comment on Study
Gonzalez SD, 2013	SNP: rs1380455, rs16914968, rs1551684, rs3808942, rs3808943, rs10994336 Haplotype: rs1380455 - rs16914968 - rs1551684 - rs3808942 - rs3808943 - rs10994336 (T-C-C-T-T-T ), rs1380455 - rs16914968 - rs1551684 - rs3808942 - rs3808943 - rs10994336 (G-C-C-T-C-C ), rs1380455 - rs16914968 - rs1551684 - rs3808942 - rs3808943 - rs10994336 (T-C-C-C-C-C ), rs1380455 - rs16914968 - rs1551684 - rs3808942 - rs3808943 - rs10994336 (T-C-T-T-C-C ), rs1380455 - rs16914968 - rs1551684 - rs3808942 - rs3808943 - rs10994336 (T-T-C-T-C-C )	These results provide additional evidence that ANK3 is associated with BP and provide the first evidence that variations in this gene might have a role in the pathogenesis of this disorder in the Latino population.	Positive	Comment on Study
Kondo, K.,2013	SNP: rs10994336	No significant association was observed.	Negative	Comment on Study
Dedman, A.,2012	SNP: rs10821668, rs10821792, rs10994285, rs10994336, rs10994397, rs11599164, rs139092048, rs142415903, rs185539081, rs1938526, rs2018783, rs28932171, rs41274672, rs61845768	Four SNPs were found to be nominally associated with bipolar disorder in UCL1.But ANK3 association with bipolar disorder was not detected in the UCL2 replication cohort and this indicates that there is heterogeneity for bipolar disorder susceptibility genes even within a single ancestrally selected group of cases and controls.	Positive	Comment on Study
Green, E. K.,2012	SNP: rs10994397	BD ImmunoChip:P-value = 0.923,OR = 1.01;ImmunoChip, PGC-BD combined data:P-balue = 0.00000215,OR = 0.842 Suggestive association was found.	Trend	Comment on Study
Doyle, G. A., 2012	Other variant: ANK3_exon 48_P1489S, ANK3_exon 48_T1861M, ANK3_exon 48_E1926D, ANK3_exon 48_S2043N, ANK3_exon 48_I2158T, ANK3_exon 48_D2319N, ANK3_exon 48_F2375V, ANK3_exon 48_S2409P, ANK3_exon 48_N2643S, ANK3_exon 48_R2719T, ANK3_exon 48_G2845E, ANK3_exon 48_S2858L, ANK3_exon 48_Q3264K, ANK3_exon 48_S3521G, ANK3_exon 48_E3563G, ANK3_exon 48_S3697C, ANK3_exon 48_N3789S, ANK3_exon 48_K3942R	We found no statistically significant association of any of the rare variants detected with BPD-I. Conclusions: Thus, we conclude that rare variants within the re-sequenced structural domains of ANK3 exon 48 do not contribute to BPD-I.	Negative	Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013	SNP: rs10994397	Significant association was observed in BPD.	Positive	Comment on Study
Muhleisen, T. W., 2014	SNP: rs10994415, rs10994397, rs1938540, rs10821745, rs10821736, rs10994430, rs10994336, rs10994308, rs10509129	The most significant association signal and the largest number of genome-wide significant SNPs (n=26) were identified in ANK3 (ankyrin 3) on chromosome 10q21.2 rs10994415-C, PGC=6.88E-11,OR=1.27).	Positive	Comment on Study
Lim C.H., 2014	SNP: rs1938526, rs10994336	Following stratification by ethnicity, variants of the ANK3 gene (rs1938526 and rs10994336) were found to be associated with BPD in Malays (P-value=0.001 and0.006, respectively).	Positive	Comment on Study
Sklar, P.,2011	SNP: rs10994397, rs9804190	Significant association was found.	Positive	Comment on Study
Liu, Y.,2011	SNP: rs10994336, rs10994338	Significant associations were found in rs10994336 and rs10994338.	Positive	Comment on Study
Gella, A.,2011	SNP: rs10761482, rs10994336, rs9804190	Our results support a specific genetic contribution of ANK3 to bipolar disorder though we failed to replicate findings for schizophrenia.	Positive	Comment on Study
Schulze, T. G.,2009	SNP: rs10994336, rs9804190	Our findings strongly support ANK3 as a BD susceptibility gene and suggest true allelic heterogeneity.	Positive	Comment on Study
Chen, D. T.,2011	SNP: rs4948418	Supportive evidence for prior association findings near ANK3 was also observed.	Positive	Comment on Study
Lett, T. A.,2011	SNP: rs10994336, rs9804190	No significant association was observed in ANK3 gene for BPD.	Negative	Comment on Study
Tesli, M.,2011	SNP: rs10994336, rs1938526, rs9804190	These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved.	Positive	Comment on Study
Takata, A.,2011(b)	SNP: rs10994336, rs1938526	We detected a nominal association between rs1938526 in ANK3 and BD.	Positive	Comment on Study

Region: chr10:60026298..60733490 View in gBrowse