Gene Report

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Basic Info

Approved Symbol	KCND2
Symbol Alias	Kv4.2, RK5, KIAA1044
Approved Name	potassium channel, voltage gated Shal related subfamily D, member 2
Previous Name	potassium voltage-gated channel, Shal-related subfamily, member 2
Location	7q31
Position	chr7:120273668-120750331, 1
External Links	HGNC: 6238 Entrez Gene: 3751 Ensembl: ENSG00000184408 UCSC: uc003vjj.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		KCND2 has been implicated in BPD and autism spectrum disorder.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045211	postsynaptic membrane	cellular component	ISS	68
GO:0008076	voltage-gated potassium channel complex	cellular component	IDA[15454437]	8
GO:0005249	voltage-gated potassium channel activity	molecular function	IDA[24811166]; ISS; NAS[11102480]	5
GO:0016021	integral component of membrane	cellular component	IBA	219
GO:0007268	synaptic transmission	biological process	TAS[11102480]	116
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005251	delayed rectifier potassium channel activity	molecular function	IBA	3
GO:0005887	integral component of plasma membrane	cellular component	IDA[24811166]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0034765	regulation of ion transmembrane transport	biological process	IEA	16
GO:0005515	protein binding	molecular function	IPI[11287421]	563
GO:0044853	plasma membrane raft	cellular component	ISS	1
GO:0031226	intrinsic component of plasma membrane	cellular component	IMP[15454437]	3
GO:0051260	protein homooligomerization	biological process	IEA	13
GO:0071805	potassium ion transmembrane transport	biological process	IBA; IDA[15454437]	9
GO:0043204	perikaryon	cellular component	IEA	17
GO:0071456	cellular response to hypoxia	biological process	ISS	13
GO:0005250	A-type (transient outward) potassium channel activity	molecular function	IBA; IMP[15454437]; ISS	1
GO:0030054	cell junction	cellular component	IEA	88
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0001508	action potential	biological process	TAS[11102480]	6
GO:0032809	neuronal cell body membrane	cellular component	ISS	3
GO:0043197	dendritic spine	cellular component	ISS; NAS[11102480]	21

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
KCND2	NCS1	NO	in vivo	11606724
KCND2	KCNIP2	NO	in vitro	11287421
KCND2	IL16	NO	yeast 2-hybrid	10479680
KCND2	KCNIP4	YES	in vivo	11847232
KCND2	DLG4	NO	in vitro;yeast 2-hybrid	12435606
KCND2	FLNC	NO	in vitro;yeast 2-hybrid	11102480
KCND2	KCNIP1	NO	in vitro	15184042

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q31.3	chr7:117700000-127500000	0
7q31.31	chr7:117700000-121400000	1 (0/0/1)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q31-33	chr7:107800000-138500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:120273668..120750331 View in gBrowse