Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	LMLN
Symbol Alias	Gp63, Msp
Approved Name	leishmanolysin-like (metallopeptidase M8 family)
Location	3q29
Position	chr3:197960200-198043720, 1
External Links	HGNC: 15991 Entrez Gene: 89782 Ensembl: ENSG00000185621 UCSC: uc010iar.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs6605321 Haplotype: rs9880989 - rs6605321()	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IEA	137
GO:0004222	metalloendopeptidase activity	molecular function	IEA	8
GO:0007155	cell adhesion	biological process	IEA	42

GO terms by database search (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051301	cell division	biological process	IEA	20
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0005811	lipid particle	cellular component	IEA	2
GO:0005925	focal adhesion	cellular component	IDA	32
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0007067	mitotic nuclear division	biological process	IEA	15
GO:0006508	proteolysis	biological process	IEA	34

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 15)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6605321	chr3:197973124 - 197973124(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 14)

rs_ID	Location	Functional Annotation
rs6803917	chr3:197997747 - 197997747(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs6768307	chr3:198001039 - 198001039(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs7374380	chr3:197980051 - 197980051(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs7373977	chr3:197989109 - 197989109(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6422711	chr3:198023782 - 198023782(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs12630618	chr3:198025315 - 198025315(1)	intron_variant; non_coding_transcript_variant
rs6777369	chr3:198008846 - 198008846(1)	intron_variant; non_coding_transcript_variant
rs13327370	chr3:198017327 - 198017327(1)	intron_variant; non_coding_transcript_variant
rs7428537	chr3:197977281 - 197977281(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6605322	chr3:197977629 - 197977629(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs7431003	chr3:197962339 - 197962339(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs9877500	chr3:197957067 - 197957067(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs6763543	chr3:198040075 - 198040075(1)	3_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs6768029	chr3:198030882 - 198030882(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:197960200..198043720 View in gBrowse