Gene Report

Basic Info
Approved Symbol ATP1A2
Previous Symbol MHP2
Symbol Alias FHM2
Approved Name ATPase, Na+/K+ transporting, alpha 2 polypeptide
Previous Name migraine, hemiplegic 2, "ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide"
Name Alias sodium/potassium-transporting ATPase subunit alpha-2, "sodium pump subunit alpha-2", "sodium-potassium ATPase catalytic subunit alpha-2"
Location 1q23.2
Position chr1:160115759-160143591, 1
External Links HGNC: 800
Entrez Gene: 477
Ensembl: ENSG00000018625
UCSC: uc001fvc.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Goldstein, I.,2009 SNP: rs2070704, rs2295623
Haplotype: rs2070704 - rs2295623()
In summary, this study demonstrates for the first time that genetic variations in tagging SNPs in the three genes of isoforms of Na<sup>+</sup , K<sup>+</sup> -ATPase are associated with BD and suggest the role of this enzyme in the etiology of BD. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 49)

GO terms by PBA (count: 3)

GO terms by database search (count: 46)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 4)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:160115759..160143591 View in gBrowse
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