Gene Report

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Basic Info

Approved Symbol	RBM23
Previous Symbol	RNPC4
Symbol Alias	FLJ10482, CAPERbeta
Approved Name	RNA binding motif protein 23
Previous Name	RNA-binding region (RNP1, RRM) containing 4
Name Alias	coactivator of activating protein-1 and estrogen recep- tors beta
Location	14q11.1
Position	chr14:22893206-22919184, -1
External Links	HGNC: 20155 Entrez Gene: 55147 Ensembl: ENSG00000100461 UCSC: uc001whg.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs10151270	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[22365833]	563
GO:0000166	nucleotide binding	molecular function	IEA	17
GO:0006397	mRNA processing	biological process	IEA	8
GO:0003723	RNA binding	molecular function	IEA	14

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RBM23	GTF3C1	NO	yeast 2-hybrid	16169070
RBM23	MED31	NO	yeast 2-hybrid	16169070
RBM23	TUBA4A	NO	yeast 2-hybrid	16169070
RBM23	RPA1	NO	yeast 2-hybrid	16169070
RBM23	PGR	NO	in vitro	15694343
RBM23	POLA2	NO	yeast 2-hybrid	16169070
RBM23	PTN	NO	yeast 2-hybrid	16169070
RBM23	KIAA1377	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10151270	chr14:22903855 - 22903855(1)	downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q11.2	chr14:18200000-24100000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)
14q11.2-12.0	chr14:18200000-32900000	1 (0/1/0)
14q11.2-14q12	chr14:18200000-32900000	1 (0/0/1)
14q11.2-q13.1	chr14:18200000-34800000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr14:22893206..22919184 View in gBrowse