Gene Report

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Basic Info

Approved Symbol	PARD6B
Symbol Alias	PAR-6B
Approved Name	par-6 family cell polarity regulator beta
Previous Name	par-6 (partitioning defective 6, C.elegans) homolog beta, "par-6 partitioning defective 6 homolog beta (C. elegans)"
Location	20q13.13
Position	chr20:50731544-50756795, 1
External Links	HGNC: 16245 Entrez Gene: 84612 Ensembl: ENSG00000124171 UCSC: uc002xvo.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2011	SNP: rs6122972	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[12545177]; TAS	360
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006461	protein complex assembly	biological process	IDA[12545177]	11
GO:0051301	cell division	biological process	IEA	20
GO:0007049	cell cycle	biological process	IEA	6
GO:0007163	establishment or maintenance of cell polarity	biological process	TAS[14676191]	5
GO:0005938	cell cortex	cellular component	IEA	7
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0045177	apical part of cell	cellular component	IEA	13
GO:0005829	cytosol	cellular component	TAS	223
GO:0007409	axonogenesis	biological process	TAS[14676191]	11
GO:0070830	tight junction assembly	biological process	TAS	2
GO:0007043	cell-cell junction assembly	biological process	TAS[12545177]	1
GO:0045216	cell-cell junction organization	biological process	TAS	8
GO:0005923	tight junction	cellular component	IDA[12545177]	13
GO:0043234	protein complex	cellular component	IEA	27
GO:0034329	cell junction assembly	biological process	TAS	8
GO:0005515	protein binding	molecular function	IPI[11260256]	563
GO:0030334	regulation of cell migration	biological process	TAS[14676191]	9
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04530	Tight junction	18

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 14)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PARD6B	RAC1	YES	in vitro;yeast 2-hybrid	11260256
PARD6B	MPP5	NO	in vitro;in vivo	12545177
PARD6B	TCP10	YES	yeast 2-hybrid	10934474
PARD6B	PRKCG	NO	in vivo	14676191
PARD6B	PARD6A	NO	in vivo	14676191
PARD6B	CDC42	NO	in vitro;in vivo	14676191 , 11260256 , 10934474
PARD6B	PARD3B	YES	in vitro	12234671
PARD6B	PRKCI	NO	in vitro;in vivo;yeast 2-hybrid	14676191
PARD6B	HTRA1	NO	yeast 2-hybrid	15101818
PARD6B	YWHAZ	NO	in vivo	14676191
PARD6B	YWHAB	NO	in vivo	14676191
PARD6B	PARD3	NO	in vitro	12459187 , 14676191
PARD6B	RHOQ	NO	in vitro;yeast 2-hybrid	10934474
PARD6B	PNMA1	NO	in vivo	14676191

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6122972	chr20:50758705 - 50758705(1)	downstream_gene_variant	1(0/0/1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs6126086		chr20:50743530 - 50743530(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q13	chr20:43100000-64444167	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:50731544..50756795 View in gBrowse