Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ZSCAN31
Previous Symbol	ZNF310P, ZNF323
Approved Name	zinc finger and SCAN domain containing 31
Previous Name	zinc finger protein 310 pseudogene, "zinc finger protein 323"
Location	6p
Position	chr6:28324693-28356271, -1
External Links	HGNC: 14097 Entrez Gene: 64288 Ensembl: ENSG00000235109 UCSC: uc003nla.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Saito T., 2014	SNP: rs7759855	The associated SNP in this gene showed significant association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66
GO:0005634	nucleus	cellular component	IEA	283
GO:0003677	DNA binding	molecular function	IEA	83

GO terms by database search (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 17)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7759855	chr6:28315086 - 28315086(1)	downstream_gene_variant	1(1/0/0)

LD-proxies (count: 16)

rs_ID	Location	Functional Annotation
rs7752448	chr6:28333322 - 28333322(1)	downstream_gene_variant; intron_variant
rs9461450	chr6:28320748 - 28320748(1)	downstream_gene_variant; upstream_gene_variant
rs13217619	chr6:28338894 - 28338894(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6456812	chr6:28332105 - 28332105(1)	downstream_gene_variant; intron_variant
rs6902583	chr6:28327756 - 28327756(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs6922161	chr6:28327560 - 28327560(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs6922302	chr6:28327533 - 28327533(1)	5_prime_UTR_variant; downstream_gene_variant; missense_variant; splice_region_variant; upstream_gene_variant
rs758398	chr6:28352897 - 28352897(1)	intron_variant; non_coding_transcript_variant
rs6910120	chr6:28332539 - 28332539(1)	downstream_gene_variant; intron_variant
rs7752721	chr6:28333390 - 28333390(1)	downstream_gene_variant; intron_variant
rs9295769	chr6:28336792 - 28336792(1)	5_prime_UTR_variant; downstream_gene_variant; intron_variant; splice_region_variant; upstream_gene_variant
rs6908459	chr6:28337716 - 28337716(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6901001	chr6:28343342 - 28343342(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6918631	chr6:28344679 - 28344679(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6929449	chr6:28346025 - 28346025(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6456817	chr6:28346645 - 28346645(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_123	chr6:27870166-28498379 (Affymetrix SNP 6.0 array reference genome)	628213		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p22	chr6:15200000-30500000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
24888570	The associated SNP in this gene showed significant association with SZ.	Positive

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr6:28324693..28356271 View in gBrowse