Gene Report

Basic Info
Approved Symbol CRHR2
Symbol Alias CRF2, CRF-RB, HM-CRF
Approved Name corticotropin releasing hormone receptor 2
Location 7p14.3
Position chr7:30651943-30700129, -1
External Links HGNC: 2358
Entrez Gene: 1395
Ensembl: ENSG00000106113
UCSC: uc003tbp.3
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
De Luca, V., 2007 Haplotype: CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n(5-7-8 ), CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n(5-2-3), CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n(5-7-7), CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n(5-3-6), CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n(3-3-7), CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n(5-3-3), CRHR2_intron 4_(CA)n - CRHR2_intron10_(GAT)n - CRHR2_intron10_(GT)n(5-2-5)
Other variant: CRHR2_intron10_(GAT)n, CRHR2_intron10_(GT)n, CRHR2_intron4_(CA)n
One polymorphism and risk haplotypes are associated with the disease Positive Comment on Study
Villafuerte, S. M.,2002 Other variant: CRHR2_1047G/A No statistically significant evidence of CRHR2 1047G/A for the presence of an excess of longer alleles in the patient population, as compared to ethnically matched controls, was found. Negative Comment on Study
Ceulemans, S.,2011 SNP: rs10265589, rs1049402, rs1076292, rs10951271, rs11553502, rs11979352, rs17159289, rs2014663, rs2190242, rs2240403, rs2267712, rs2267715, rs2267716, rs2284216, rs2709772, rs2709778, rs2709809, rs4266550, rs4723000, rs973002 Significant associations were detected in BD patients. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 3)

GO terms by database search (count: 10)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 39)

Literature-origin SNPs (count: 20)

LD-proxies (count: 19)

Gene related CNVs (count: 0)

Gene related other variants (count: 4)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr7:30651943..30700129 View in gBrowse
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