Gene Report

Basic Info
Approved Symbol NTRK2
Symbol Alias TRKB
Approved Name neurotrophic tyrosine kinase, receptor, type 2
Location 9q22.1
Position chr9:84668551-85027070, 1
External Links HGNC: 8032
Entrez Gene: 4915
Ensembl: ENSG00000148053
UCSC: uc004anz.1
No. of Studies 3 (Positive: 1; Negative: 1; trend: 1)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Smith, E. N.,2009 SNP: rs2769605 For the AA sample, SNPs with the strongest statistical evidence for association included rs2111504 in DPY19L3 at 19q13.11 (P=1.5E-06) and rs2769605 in NTRK2 at 9q21.33 (P=4.5E-05). Trend Comment on Study
Soronen, P.,2011 SNP: rs3654 No significant association of this gene was observed in BD. Negative Comment on Study
Wang, Z., 2013 SNP: rs2769605, rs1565445, rs1387923 However, no significant association between NTRK2 gene polymorphisms and BP I susceptibility was observed after correcting for multiple comparisons. The results suggest that the NTRK2 gene polymorphism likely plays an essential role in treatment response to mood stabilizers in Han Chinese BP I patients. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 63)

GO terms by PBA (count: 4)

GO terms by database search (count: 59)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 22)

Related other genetic factors
Gene related SNPs (count: 49)

Literature-origin SNPs (count: 4)

LD-proxies (count: 45)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 4)

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Region: chr9:84668551..85027070 View in gBrowse
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