Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Comment on Gene

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Basic Info

Approved Symbol	MCHR1
Previous Symbol	GPR24
Symbol Alias	SLC1, MCH1R
Approved Name	melanin-concentrating hormone receptor 1
Previous Name	G protein-coupled receptor 24
Location	22q13.3
Position	chr22:40678750-40682814, 1
External Links	HGNC: 4479 Entrez Gene: 2847 Ensembl: ENSG00000128285 UCSC: uc003ayz.3
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Severinsen, J. E., 2006 (a)	SNP: rs133068, rs133069, rs133070, rs133073 Haplotype: D22S279 - rs133068 - rs133069 - rs133070 - rs133073(7-C-C-A-T), D22S279 - rs133068 - rs133069 - rs133070 - rs133073(6-C-C-A-T), D22S279 - rs133068 - rs133069 - rs133070 - rs133073(6/7-C-C-A-T), rs133068 - D22S279 (), rs133069 - rs133068 (), rs133069 - rs133068 - D22S279(), rs133069 - rs133070(A-G), rs133069 - rs133070 - rs133073(A-G-C), rs133070 - rs133069 (), rs133070 - rs133069 - rs133068(), rs133070 - rs133069 - rs133068 - D22S279 (), rs133070 - rs133073(A-C), rs133070 - rs133073(G-C), rs133073 - rs133070 (), rs133073 - rs133070 - rs133069 - rs133068 - D22S279 (), rs133073 - rs133070 - rs133069(), rs133073 - rs133070 - rs133069 - rs133068 (), rs133068 - D22S279 - rs909669(), rs133069 - rs133068 - D22S279 - rs909669(), rs133070 - rs133069 - rs133068 - D22S279 - rs909669 (), rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-7-C-C-A), rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6-C-C-A), rs909669 - D22S279 - rs133068 - rs133069 - rs133070(C-6/7-C-C-A), rs1573745 - rs710193 - rs133073(), rs1573745 - rs710193 - rs133073 - rs133070(), rs1573745 - rs710193 - rs133073 - rs133070 - rs133069(), rs710193 - rs133073 (), rs710193 - rs133073 - rs133070(), rs710193 - rs133073 - rs133070 - rs133069 (), rs710193 - rs133073 - rs133070 - rs133069 - rs133068 ()	Evidence from both samples suggested GPR24 as a susceptibility gene for both BPD and SZ.	Positive	Comment on Study
Yosifova, A.,2009	SNP: rs133068, rs133069, rs133070, rs133073	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0008188	neuropeptide receptor activity	molecular function	TAS[10860944]	5
GO:0005887	integral component of plasma membrane	cellular component	TAS[10421367]	158

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	TAS[10421367]	10
GO:0031513	nonmotile primary cilium	cellular component	ISS	2
GO:0006091	generation of precursor metabolites and energy	biological process	TAS[10421367]	5
GO:0051928	positive regulation of calcium ion transport	biological process	IEA	9
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[10421368]	64
GO:0007218	neuropeptide signaling pathway	biological process	IEA	18
GO:0060170	ciliary membrane	cellular component	IEA	4
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA	21
GO:0008022	protein C-terminus binding	molecular function	IEA	21
GO:0030273	melanin-concentrating hormone receptor activity	molecular function	IEA	1
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[10421367]	26
GO:0042562	hormone binding	molecular function	IEA	3
GO:0007631	feeding behavior	biological process	TAS[10421367]	12

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MCHR1	ZMYND19	NO	in vitro;yeast 2-hybrid	12208518
MCHR1	PMCH	YES	in vitro	11478907 , 11839762

Related other genetic factors

Gene related SNPs (count: 7)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs133069	chr22:40678458 - 40678458(1)	upstream_gene_variant	2(0/2/0)
rs133070	chr22:40678769 - 40678769(1)	5_prime_UTR_variant; upstream_gene_variant	2(1/1/0)
rs133073	chr22:40679691 - 40679691(1)	intron_variant; non_coding_transcript_variant; synonymous_variant; upstream_gene_variant	2(0/2/0)
rs133068	chr22:40678403 - 40678403(1)	upstream_gene_variant	2(0/2/0)

LD-proxies (count: 3)

rs_ID	Location	Functional Annotation
rs133063	chr22:40675655 - 40675655(1)	upstream_gene_variant
rs133064	chr22:40675727 - 40675727(1)	upstream_gene_variant
rs133072	chr22:40679539 - 40679539(1)	intron_variant; missense_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q12.3-13.32	chr22:31800000-49100000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
16741940	Evidence from both samples suggested GPR24 as a susceptibility gene for both BPD and SZ.	Positive

Overlap with SZ from candidate gene intersection analysis (count: 3)

Reference	ID in SZGene	Result Category
16741940	440	Positive
19158809	440	Negative
19502010	440	Positive

Gene relationship with MDD

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Region: chr22:40678750..40682814 View in gBrowse