Gene Report

Basic Info
Approved Symbol PER2
Symbol Alias KIAA0347
Approved Name period circadian clock 2
Previous Name period (Drosophila) homolog 2, "period homolog 2 (Drosophila)"
Location 2q37.3
Position chr2:238244038-238290102, -1
External Links HGNC: 8846
Entrez Gene: 8864
Ensembl: ENSG00000132326
UCSC: uc002vyc.3
No. of Studies 7 (Positive: 1; Negative: 6; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 7)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kripke, D. F.,2009 SNP: rs2304669, rs2304672, rs4663868 Significant association was observed in the BP group. Positive Comment on Study
Byrne, E. M., 2014 P-value=0.45. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Nievergelt, C. M., 2006 Single SNP TDT analyses showed no evidence for association to BPAD. Negative Comment on Study
Shiino, Y.,2003 Other variant: PER2_2087A/G, PER2_2114G/A, PER2_2117G/A Polymorphism on the CKIepsilon binding region of hper2 gene which was previously reported, is unlikely to play an important role in the development of bipolar disorder. Negative Comment on Study
Mansour, H. A., 2006 No significant association was detected in any sample using any test. Negative Comment on Study
Mansour, H. A.,2009 SNP: rs2304672, rs2304674 Gene-based tests:X<sup>2</sup>=7.226, P-value = 0.062 in recessive model, X<sup>2</sup>=3.587, P-value = 0.336 in additive model, X<sup>2</sup>=1.828, P-value = 0.849 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Soria, V.,2010 SNP: rs2304673 No significant associations of PER2 gene were found in BPD patients. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 44)

GO terms by PBA (count: 2)

GO terms by database search (count: 42)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 21)

Literature-origin SNPs (count: 5)

LD-proxies (count: 16)

Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr2:238244038..238290102 View in gBrowse
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