Gene Report

Basic Info
Approved Symbol MED12
Previous Symbol TNRC11, FGS1
Symbol Alias CAGH45, HOPA, OPA1, TRAP230, KIAA0192, OKS
Approved Name mediator complex subunit 12
Previous Name trinucleotide repeat containing 11 (THR-associated protein, 230kDa subunit), "mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)", "FG syndrome 1"
Location Xq13
Position chrX:71118556-71142454, 1
External Links HGNC: 11957
Entrez Gene: 9968
Ensembl: ENSG00000184634
UCSC: uc004dyy.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kirov, G.,2003 Other variant: MED12_exon42_duplication We conclude that the HOPA polymorphism is unlikely to be a major risk factor in the pathogenesis of these major psychiatric disorders although there could be a small effect in schizophrenia. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 35)

GO terms by PBA (count: 4)

GO terms by database search (count: 31)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 4)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chrX:71118556..71142454 View in gBrowse
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