Gene Report

Basic Info
Approved Symbol CIT
Symbol Alias KIAA0949, STK21, CRIK
Approved Name citron rho-interacting serine/threonine kinase
Previous Name citron (rho-interacting, serine/threonine kinase 21)
Name Alias serine/threonine kinase 21
Location 12q24.23
Position chr12:119685790-119877291, -1
External Links HGNC: 1985
Entrez Gene: 11113
Ensembl: ENSG00000122966
UCSC: uc001txj.2
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Lyons-Warren, A.,2005 SNP: rs203368, rs435136
Haplotype: rs203368 - rs435136(A-C), rs203368 - rs435136(G-T), rs203368 - rs435136 - hCV3259834(A-C-G), rs203368 - rs435136 - hCV3259834(G-T-A), rs2285595 - rs278109 - rs203368 - rs435136 - hCV3259834(T-A-G-T-A), rs278109 - rs203368(G-A), rs278109 - rs203368 - rs435136 - hCV3259834(A-G-T-A), rs278124 - rs278109 - rs203368(C-G-A), rs278124 - rs278109 - rs203368 - rs435136(C-G-A-C), rs435136 - hCV3259834(C-G), rs435136 - hCV3259834(T-A)
Our evidence suggests a possible association of the Citron gene and BP in a family-based sample set.It is conceivable that Citron is one of a cluster of susceptibility genes for BP in the chromosomal region of 12q23-24. Positive Comment on Study
Yosifova, A.,2009 SNP: rs203368, rs2074052, rs2285595, rs278109, rs435136, rs4766951 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 28)

GO terms by PBA (count: 6)

GO terms by database search (count: 22)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 85)

Literature-origin SNPs (count: 6)

LD-proxies (count: 79)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr12:119685790..119877291 View in gBrowse
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