Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ARRB2
Previous Symbol	ARR2
Symbol Alias	BARR2, DKFZp686L0365
Approved Name	arrestin, beta 2
Name Alias	arrestin 3
Location	17p13
Position	chr17:4710489-4721499, 1
External Links	HGNC: 712 Entrez Gene: 409 Ensembl: ENSG00000141480 UCSC: uc002fyl.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Shi, J., 2008 (b)	SNP: rs4790694	Significant associations of this gene were found in BPD patients.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 67)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA[18604210]; TAS[21149639]	360
GO:0007420	brain development	biological process	IEA	25
GO:0045211	postsynaptic membrane	cellular component	IEA	68
GO:0005634	nucleus	cellular component	IDA[16820410]	283
GO:0019904	protein domain specific binding	molecular function	IEA	24
GO:0005102	receptor binding	molecular function	IPI[18604210]	37

GO terms by database search (count: 61)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA[12958365]	322
GO:0005829	cytosol	cellular component	TAS	223
GO:0031762	follicle-stimulating hormone receptor binding	molecular function	IEA	1
GO:0016567	protein ubiquitination	biological process	IMP[15878855]	18
GO:0060326	cell chemotaxis	biological process	IMP[15635042]	4
GO:0007179	transforming growth factor beta receptor signaling pathway	biological process	IDA[12958365]	5
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	IMP[15878855]	13
GO:0032947	protein complex scaffold	molecular function	IDA[19372219]	5
GO:0034122	negative regulation of toll-like receptor signaling pathway	biological process	IEA	1
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	biological process	IEA	2
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	biological process	IMP[18604210]	1
GO:0002092	positive regulation of receptor internalization	biological process	IMP[22457824]	4
GO:0007219	Notch signaling pathway	biological process	TAS	14
GO:0071889	14-3-3 protein binding	molecular function	IEA	7
GO:0032720	negative regulation of tumor necrosis factor production	biological process	IEA	5
GO:0043197	dendritic spine	cellular component	IEA	21
GO:0060765	regulation of androgen receptor signaling pathway	biological process	IDA[19372219]	1
GO:0051897	positive regulation of protein kinase B signaling	biological process	IEA	11
GO:0032226	positive regulation of synaptic transmission, dopaminergic	biological process	IEA	2
GO:0001664	G-protein coupled receptor binding	molecular function	IPI[10644702]	9
GO:0032695	negative regulation of interleukin-12 production	biological process	IEA	3
GO:0034260	negative regulation of GTPase activity	biological process	IEA	2
GO:0031692	alpha-1B adrenergic receptor binding	molecular function	IEA	2
GO:0031410	cytoplasmic vesicle	cellular component	IDA[12958365]	7
GO:0006366	transcription from RNA polymerase II promoter	biological process	IDA[16820410]	31
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological process	IDA[15125834]	6
GO:0042699	follicle-stimulating hormone signaling pathway	biological process	IEA	1
GO:0030168	platelet activation	biological process	TAS	22
GO:0031398	positive regulation of protein ubiquitination	biological process	IGI[19372219]	5
GO:0015031	protein transport	biological process	IEA	21
GO:0032691	negative regulation of interleukin-1 beta production	biological process	IEA	1
GO:0016323	basolateral plasma membrane	cellular component	IEA	21
GO:0033138	positive regulation of peptidyl-serine phosphorylation	biological process	IEA	10
GO:0032715	negative regulation of interleukin-6 production	biological process	IEA	4
GO:0031397	negative regulation of protein ubiquitination	biological process	IDA[16378096]	6
GO:0031748	D1 dopamine receptor binding	molecular function	IEA	5
GO:0031701	angiotensin receptor binding	molecular function	IPI[15611106]	1
GO:0031826	type 2A serotonin receptor binding	molecular function	IEA	1
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IEA	12
GO:2000573	positive regulation of DNA biosynthetic process	biological process	IEA	1
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	biological process	IMP[12582207]	2
GO:0051928	positive regulation of calcium ion transport	biological process	IEA	9
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IDA[10644702]; IMP[12582207]	14
GO:0005905	coated pit	cellular component	IEA	4
GO:0031702	type 1 angiotensin receptor binding	molecular function	IEA	3
GO:0007628	adult walking behavior	biological process	IEA	9
GO:0005515	protein binding	molecular function	IPI[12958365]	563
GO:0051019	mitogen-activated protein kinase binding	molecular function	IEA	3
GO:0090201	negative regulation of release of cytochrome c from mitochondria	biological process	IEA	5
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[15878855]	25
GO:0031691	alpha-1A adrenergic receptor binding	molecular function	IEA	1
GO:0019899	enzyme binding	molecular function	IPI[23382074]	34
GO:0007596	blood coagulation	biological process	TAS	44
GO:0034392	negative regulation of smooth muscle cell apoptotic process	biological process	IEA	2
GO:0031623	receptor internalization	biological process	IDA[12958365]	5
GO:0032403	protein complex binding	molecular function	IEA	16
GO:0030139	endocytic vesicle	cellular component	IDA[23341447]	8
GO:0043422	protein kinase B binding	molecular function	IEA	1
GO:0002031	G-protein coupled receptor internalization	biological process	IDA[10644702]; IMP[12582207]	4
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IEA	5

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04010	MAPK signaling pathway	39

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04740	Olfactory transduction	11

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 36)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ARRB2	NFKBIA	NO	in vitro;in vivo;yeast 2-hybrid	15125834 , 15173580
ARRB2	NTS	YES	in vitro;in vivo	12473660
ARRB2	NDUFS7	NO	yeast 2-hybrid	16169070
ARRB2	SLC9A5	NO	in vitro;in vivo;yeast 2-hybrid	15699339
ARRB2	HTR2C	YES	in vivo	18768750
ARRB2	CLTC	YES	in vivo;yeast 2-hybrid	10097102 , 17666399
ARRB2	MAP3K5	NO	in vivo	11356842
ARRB2	STC2	NO	yeast 2-hybrid	16169070
ARRB2	CSNK2A1	YES	in vitro;in vivo	11877451
ARRB2	AVPR2	NO	in vitro;in vivo	12473660
ARRB2	CYTH2	NO	in vitro;in vivo	11533043
ARRB2	FZD4	NO	in vivo	12958364
ARRB2	NTSR1	NO	in vivo	11279203
ARRB2	AP2M1	NO	in vivo	17666399
ARRB2	ADRB2	YES	in vivo	17666399
ARRB2	FLNA	NO	in vitro;in vivo;yeast 2-hybrid	16611986
ARRB2	OXTR	YES	in vivo	11279203
ARRB2	MAPK1	NO	in vitro	11226259
ARRB2	AGTR1	YES	in vivo	11279203
ARRB2	TRH	YES	in vitro;in vivo	12473660
ARRB2	ARF6	NO	in vitro;in vivo	11533043 , 11867621
ARRB2	OPRD1	NO	in vivo	11259507
ARRB2	RALGDS	NO	in vivo;yeast 2-hybrid	12105416
ARRB2	MAPK10	YES	in vivo;yeast 2-hybrid	11090355 , 11356842
ARRB2	MED8	NO	yeast 2-hybrid	16169070
ARRB2	MDM2	NO	in vivo	12538596 , 12488444 , 11588219
ARRB2	TGFBR3	NO	in vivo	12958365
ARRB2	SMARCC2	NO	yeast 2-hybrid	16169070
ARRB2	C5AR1	NO	in vivo	12464600
ARRB2	CXCR4	NO	in vivo	10644702
ARRB2	DVL2	NO	in vivo	12958364
ARRB2	CSNK2A2	NO	in vitro;in vivo	11877451
ARRB2	AP1B1	NO	in vitro;in vivo;yeast 2-hybrid	10097102 , 12070169
ARRB2	RAF1	NO	in vitro	11226259
ARRB2	HIPK3	NO	yeast 2-hybrid	15231748
ARRB2	PTAFR	NO	in vitro;in vivo	11729201 , 9037196

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4790694	chr17:4723059 - 4723059(1)	downstream_gene_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17p13	chr17:0-10800000	3 (0/3/0)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
17233643	115	Negative

Gene relationship with MDD

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Region: chr17:4710489..4721499 View in gBrowse