Gene Report

Approved Symbol	TH
Symbol Alias	DYT5b
Approved Name	tyrosine hydroxylase
Name Alias	tyrosine 3-monooxygenase
Location	11p15.5
Position	chr11:2163929-2171877, -1
External Links	HGNC: 11782 Entrez Gene: 7054 Ensembl: ENSG00000180176 UCSC: uc001lvr.3
No. of Studies	16 (Positive: 4; Negative: 12; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Nothen, M. M., 1992		No significant association between bipolar affective disorder and TH was found. Thus the hypothesis that TH is involved in the pathogenesis of bipolar affective disorder was not supported.	Negative	Comment on Study
De bruyn, A.,1994	Other variant: TH_PstI Polymorphism, TH_TaqI Polymorphism	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions	Negative	Comment on Study
Gill, M., 1991	Other variant: TH_TaqI Polymorphism, TH_BglII Polymorphism	The frequencies of the alleles in TH are not significantly different between patients and controls	Negative	Comment on Study
Leboyer, M.,1990	Other variant: TH_TaqI Polymorphism, TH_BglII Polymorphism	TaqI OR = 2.99, BglII OR = 2.4;. Our results demonstrated an association between RFLP and bipolar illness.	Positive	Comment on Study
Muglia, P.,2002	Other variant: TH_VNTR	The analysis of TH did not reveal biased transmission of intron I VNTR alleles.	Negative	Comment on Study
Serretti, A.,2000(b)	Other variant: TH_intron 1_tetranucleotide polymorphism	No significant linkage was found in this study.	Negative	Comment on Study
Korner, J.,1994	Haplotype: TH - PJ4.7 - TY7(TH4 - PJ4.7 - TY7) Other variant: TH_intron 1_tetranucleotide repeat	Association analysis: no significant differences between the groups were observed in allele frequencies in either the London (X<sup>2</sup> = 1.80, df = 4, P-value = 0.77), the Cardiff (X<sup>2</sup> = 2.04, df = 4, P-value = 0.73), or the Bonn study (X<sup>2</sup> = 7.34, df = 4, P-value = 0.12).. No significant association between bipolar affective disorder and THwas found.	Negative	Comment on Study
Perez de Castro, I.,1995	Other variant: TH_(CATT)n	X<sup>2</sup> = 9.55, df = 4, P-value<0.05. Specially for the th10 allele, the th10 allele of the TH gene was significantly more frequent in patients (0.358) than in controls (0.208) (X<sup>2</sup> = 5.81, df = 1, P-value = 0.015). After multiple correction, the th10 allele p-value = 0.15). A weak association between TH gene and bipolar affective disorder is suggested	Positive	Comment on Study
Souery, D.,1999	Other variant: TH_intron 1_tetranucleotide repeat	The results of this association study do not confirm the possible implication of TH polymorphism in the susceptibility to BPAD.	Negative	Comment on Study
Furlong, R. A.,1999(c)	Other variant: TH_intron 1_tetranucleotide repeat, TH_PstI Polymorphism	These results do not support the tyrosine hydroxylase gene having a major role in the etiology of bipolar affective disorder.	Negative	Comment on Study
Souery, D.,1996(b)	Other variant: TH_intron 1_tetranucleotide repeat	Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample.	Negative	Comment on Study
Souery, D.,1996(a)	Other variant: TH_intron 1_tetranucleotide repeat, TH_TaqI Polymorphism	The observed excess of homozygosity may indicate that a recessive variant of TH gene is involved in the susceptibility to the disease.	Positive	Comment on Study
Turecki, G., 1997	Other variant: TH_TaqI_RFLP, TH_tetranucleotide repeat	The overall odds ratio (and confidence interval) based on combining the results of the studies was 1.02 (0.68-1.54). Test of the null hypothesis that the mean log odds ratio equals zero (chi2 = 0.11; 5 df; P > 0.05) indicated that there was no overall association between bipolar disorder and tyrosine hydroxylase.	Negative	Comment on Study
Burgert, E., 1998	Other variant: TH_(TCAT)n	No association was apparent between HUMTH01 and BPD.	Negative	Comment on Study
Malafosse, A., 1997	Other variant: TH_TaqI_RFLP, TH_BglII	Taken together these results converge to suggest that the risk factors for MDI lie in the 11p15 region with TH being the most likely candidate gene.	Positive	Comment on Study
Oruc, L., 1997 (a)	Other variant: TH_1-5 allele	Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study.	Negative	Comment on Study

Region: chr11:2163929..2171877 View in gBrowse