Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TAB2
Previous Symbol	MAP3K7IP2
Symbol Alias	KIAA0733
Approved Name	TGF-beta activated kinase 1/MAP3K7 binding protein 2
Previous Name	mitogen-activated protein kinase kinase kinase 7 interacting protein 2
Location	6q25.1
Position	chr6:149218641-149411613, 1
External Links	HGNC: 17075 Entrez Gene: 23118 Ensembl: ENSG00000055208 UCSC: uc010kib.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: TAB2_Chr6:149699617_G/A	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 31)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0045087	innate immune response	biological process	TAS	49

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	biological process	TAS	2
GO:0034146	toll-like receptor 5 signaling pathway	biological process	TAS	6
GO:0000187	activation of MAPK activity	biological process	TAS	14
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	TAS	12
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	19
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IEP[12761501]	14
GO:0034134	toll-like receptor 2 signaling pathway	biological process	TAS	8
GO:0050852	T cell receptor signaling pathway	biological process	TAS	9
GO:0002224	toll-like receptor signaling pathway	biological process	TAS	10
GO:0034138	toll-like receptor 3 signaling pathway	biological process	TAS	7
GO:0070530	K63-linked polyubiquitin binding	molecular function	IDA[19935683]	3
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	biological process	TAS	8
GO:0045860	positive regulation of protein kinase activity	biological process	IDA[11460167]	8
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	biological process	TAS	8
GO:0007254	JNK cascade	biological process	TAS	8
GO:0005515	protein binding	molecular function	IPI[11460167]	563
GO:0034142	toll-like receptor 4 signaling pathway	biological process	TAS	8
GO:0007507	heart development	biological process	IMP[20493459]	20
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological process	TAS	7
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological process	TAS	7
GO:0034166	toll-like receptor 10 signaling pathway	biological process	TAS	6
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological process	TAS	8
GO:0034162	toll-like receptor 9 signaling pathway	biological process	TAS	7
GO:0007249	I-kappaB kinase/NF-kappaB signaling	biological process	TAS	2
GO:0051403	stress-activated MAPK cascade	biological process	TAS	8
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological process	TAS	5
GO:0010008	endosome membrane	cellular component	TAS	17
GO:0005829	cytosol	cellular component	TAS	223

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
TAB2_Chr6:149699617_G/A	Missense	Chr6:149699617	1 (0/0/1)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q25	chr6:148500000-160600000	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:149218641..149411613 View in gBrowse