Gene Report

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Basic Info

Approved Symbol	INA
Previous Symbol	NEF5
Symbol Alias	NF-66
Approved Name	internexin neuronal intermediate filament protein, alpha
Location	10q24
Position	chr10:103277163-103290351, 1
External Links	HGNC: 6057 Entrez Gene: 9118 Ensembl: ENSG00000148798 UCSC: uc001kws.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		3 SNP typed, Median D'=0.97, Median r<sup>2</sup> =0.88, 1 LD blocks, 0.81 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030154	cell differentiation	biological process	IEA	31

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0031965	nuclear membrane	cellular component	IDA	15
GO:0045111	intermediate filament cytoskeleton	cellular component	IDA	2
GO:0005200	structural constituent of cytoskeleton	molecular function	TAS[7769995]	9
GO:0036464	cytoplasmic ribonucleoprotein granule	cellular component	IDA[15121898]	3
GO:0021762	substantia nigra development	biological process	IEP[22926577]	7
GO:0060052	neurofilament cytoskeleton organization	biological process	IEA	1
GO:0005883	neurofilament	cellular component	IEA	4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa01430	Cell Communication	11

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
INA	STAU1	NO	in vitro	15121898
INA	GRIN2D	YES	in vivo	10862698
INA	GRIN1	YES	in vivo	10862698
INA	TANC1	NO	in vitro	15673434

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q24	chr10:95300000-104000000	4 (0/2/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
16380905	176	Negative

Gene relationship with MDD

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Region: chr10:103277163..103290351 View in gBrowse