Gene Report

Basic Info
Approved Symbol GABRA3
Approved Name gamma-aminobutyric acid (GABA) A receptor, alpha 3
Name Alias GABA(A) receptor, alpha 3
Location Xq28
Position chrX:152166234-152451358, -1
External Links HGNC: 4077
Entrez Gene: 2556
Ensembl: ENSG00000011677
UCSC: uc010ntk.1
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Puertollano, R.,1995 Other variant: GABRA3_(AC)n We have not found significant differences between controls and patients in allele frequencies or genotypes Negative Comment on Study
Massat, I.,2002(a) Other variant: GABRA3_CA repeat Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD. Positive Comment on Study
Duffy, A.,2000 Other variant: GABRA3_GDB156286 In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 15)

GO terms by PBA (count: 6)

GO terms by database search (count: 9)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 2)

BioCarta pathways by database search (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Gene related regions (count: 0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chrX:152166234..152451358 View in gBrowse
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