Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	INS
Previous Symbol	IDDM2, IDDM1
Approved Name	insulin
Previous Name	insulin-dependent diabetes mellitus 2
Location	11p15.5
Position	chr11:2159779-2161341, -1
External Links	HGNC: 6081 Entrez Gene: 3630 Ensembl: ENSG00000254647
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
De bruyn, A.,1994	Other variant: INS_PvuII Polymorphism	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 74)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005159	insulin-like growth factor receptor binding	molecular function	IPI[8452530]	5
GO:0005179	hormone activity	molecular function	IC[9667398]; IMP[381941]; NAS[14986111]	12
GO:0005158	insulin receptor binding	molecular function	IDA[7556975]; IPI[8452530]	5

GO terms by database search (count: 71)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0022898	regulation of transmembrane transporter activity	biological process	IDA[14615391]	2
GO:0032880	regulation of protein localization	biological process	IDA[14615391]	4
GO:0042177	negative regulation of protein catabolic process	biological process	IDA[15185208]	5
GO:0030335	positive regulation of cell migration	biological process	ISS[12138094]	16
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0002020	protease binding	molecular function	IPI[20082125]	10
GO:0045861	negative regulation of proteolysis	biological process	IMP[3553851]	2
GO:0045922	negative regulation of fatty acid metabolic process	biological process	IMP[1184755]	1
GO:0046889	positive regulation of lipid biosynthetic process	biological process	NAS[11742412]	5
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	biological process	IDA[7688386]	9
GO:0045908	negative regulation of vasodilation	biological process	NAS[12946932]	1
GO:0050796	regulation of insulin secretion	biological process	TAS	24
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IDA[9092559]	64
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	IDA[19727662]	12
GO:0007267	cell-cell signaling	biological process	IC[7556975]	29
GO:0030307	positive regulation of cell growth	biological process	NAS[11742412]	8
GO:0050708	regulation of protein secretion	biological process	IDA[15591776]	2
GO:0045740	positive regulation of DNA replication	biological process	IDA[7688386]	7
GO:0005796	Golgi lumen	cellular component	TAS	9
GO:0060266	negative regulation of respiratory burst involved in inflammatory response	biological process	IDA[11443198]	1
GO:0046326	positive regulation of glucose import	biological process	IDA[14615391]	7
GO:0050995	negative regulation of lipid catabolic process	biological process	IMP[24675707]; NAS[11742412]	6
GO:0042593	glucose homeostasis	biological process	IMP[381941]	19
GO:0046628	positive regulation of insulin receptor signaling pathway	biological process	IDA[7688386]	4
GO:0006521	regulation of cellular amino acid metabolic process	biological process	IMP[3553851]	3
GO:0008286	insulin receptor signaling pathway	biological process	IDA[20455999]; TAS	15
GO:0006953	acute-phase response	biological process	IDA[14739855]	3
GO:0051897	positive regulation of protein kinase B signaling	biological process	IDA[11500939]	11
GO:0055089	fatty acid homeostasis	biological process	IMP[1184755]	4
GO:0015758	glucose transport	biological process	IDA[14615391]	7
GO:0005515	protein binding	molecular function	IPI[9388210]	563
GO:0045909	positive regulation of vasodilation	biological process	NAS[14744991]	14
GO:0045597	positive regulation of cell differentiation	biological process	NAS[11742412]	1
GO:0008284	positive regulation of cell proliferation	biological process	IDA[17925406]	44
GO:0005615	extracellular space	cellular component	IDA[9667398]	85
GO:0060267	positive regulation of respiratory burst	biological process	IDA[9092559]	1
GO:0042802	identical protein binding	molecular function	IPI[20738396]	44
GO:0045840	positive regulation of mitotic nuclear division	biological process	IDA[10644978]	5
GO:0006112	energy reserve metabolic process	biological process	TAS	19
GO:0032460	negative regulation of protein oligomerization	biological process	IDA[9830016]	1
GO:0006355	regulation of transcription, DNA-templated	biological process	NAS[12881524]	62
GO:0050715	positive regulation of cytokine secretion	biological process	IDA[15473891]	3
GO:0032270	positive regulation of cellular protein metabolic process	biological process	IMP[3553851]	4
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	biological process	NAS[16604263]	4
GO:0002674	negative regulation of acute inflammatory response	biological process	IDA[11443198]	1
GO:0031018	endocrine pancreas development	biological process	TAS	6
GO:0045725	positive regulation of glycogen biosynthetic process	biological process	IDA[17925406]	3
GO:0042060	wound healing	biological process	IDA[9498508]	9
GO:0033861	negative regulation of NAD(P)H oxidase activity	biological process	IDA[11443198]	2
GO:0045818	negative regulation of glycogen catabolic process	biological process	IMP[381941]	2
GO:0031954	positive regulation of protein autophosphorylation	biological process	ISS[3518947]	2
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	NAS[14615391]	13
GO:0051000	positive regulation of nitric-oxide synthase activity	biological process	NAS[12135947]	5
GO:0006006	glucose metabolic process	biological process	IEA	10
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IDA[11278339]	12
GO:0090336	positive regulation of brown fat cell differentiation	biological process	TAS[11387233]	1
GO:0034774	secretory granule lumen	cellular component	TAS	2
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:2000252	negative regulation of feeding behavior	biological process	IDA[17957153]	3
GO:0005576	extracellular region	cellular component	IC[7556975]; TAS	97
GO:1900182	positive regulation of protein localization to nucleus	biological process	IDA[20455999]	3
GO:0005788	endoplasmic reticulum lumen	cellular component	TAS	8
GO:0090277	positive regulation of peptide hormone secretion	biological process	TAS[11387233]	1
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[11500939]	13
GO:0031904	endosome lumen	cellular component	TAS	3
GO:0045721	negative regulation of gluconeogenesis	biological process	NAS[11742412]	4
GO:0000165	MAPK cascade	biological process	IDA[11278339]	10
GO:0032148	activation of protein kinase B activity	biological process	IDA[8702995]	5
GO:0046631	alpha-beta T cell activation	biological process	IDA[10604997]	1
GO:0050709	negative regulation of protein secretion	biological process	IDA[14739855]	4
GO:0045821	positive regulation of glycolytic process	biological process	IDA[7688386]; IMP[381941]	4

Gene related KEGG pathways (count: 9)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04140	Regulation of autophagy	3

KEGG pathways by database search (count: 8)

ID	Name	No. of Genes in BDgene
hsa05215	Prostate cancer	18
hsa04950	Maturity onset diabetes of the young	3
hsa04940	Type I diabetes mellitus	10
hsa04930	Type II diabetes mellitus	11
hsa05050	Dentatorubropallidoluysian atrophy (DRPLA)	4
hsa04910	Insulin signaling pathway	10
hsa04810	Regulation of actin cytoskeleton	24
hsa04150	mTOR signaling pathway	5

Gene related BioCarta pathways (count: 4)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 4)

ID	Name	No. of Genes in BDgene
insulinPathway	Insulin Signaling Pathway	4
ghPathway	Growth Hormone Signaling Pathway	4
hdacPathway	Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)	10
pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	12

Gene related interactors from protein-protein interactions data in HPRD (count: 16)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
INS	HLA-DQA2	NO	in vitro	11376336
INS	RB1	NO	in vitro;in vivo	10938588 , 7818556
INS	IDE	NO	in vitro	11145591 , 17051221
INS	IGFBP7	YES	in vitro	9388210
INS	LRP2	NO	in vitro	9773776
INS	CTSD	NO	in vitro;in vivo	11779865
INS	HLA-DQB1	NO	in vitro	11376336
INS	GCK	NO	in vitro	12101177
INS	CTSB	NO	in vitro	6351842
INS	IGF1R	NO	in vivo	1851182
INS	CTSE	NO	in vitro	1959628 , 195962
INS	INSR	NO	in vivo	2550426
INS	NOV	NO	in vitro	10084601
INS	TXNDC17	NO	in vitro	14607844
INS	CPE	NO	in vivo	10966857 , 7477119
INS	SYTL4	NO	in vitro	10497219

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
INS_PvuII Polymorphism	SNP		1 (0/1/0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11p15	chr11:0-22000000	5 (0/4/1)
11p15.5	chr11:0-2800000	3 (1/0/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
19673036	828	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

Reference	Description	Category in MDD	Link in MK4MDD
20376317	Biological networks and signal transduction pathways corresponding to the identified gene set suggested putative dysregulated functions for several hormone-type factors previously implicated in depression (insulin, interleukin-1, thyroid hormone, estradiol and glucocorticoids; p<0.01 for association with depression-related networks).	Pos	INS

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Region: chr11:2159779..2161341 View in gBrowse