Gene Report

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Basic Info

Approved Symbol	PRSS55
Symbol Alias	T-SP1, UNQ9391, CT153
Approved Name	protease, serine, 55
Location	8p23.1
Position	chr8:10525546-10554166, 1
External Links	HGNC: 30824 Entrez Gene: 203074 Ensembl: ENSG00000184647 UCSC: uc003wta.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs6981847	The most significant SNP was rs11787406, which is located just downstream of the gene PRSS55 on 8p23.1 (p = 2.35E-6).	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006508	proteolysis	biological process	IEA	34
GO:0005829	cytosol	cellular component	IEA	223
GO:0004252	serine-type endopeptidase activity	molecular function	IEA	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6981847	chr8:10549023 - 10549023(1)	downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs7846306		chr8:10548648 - 10548648(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs4591993		chr8:10553756 - 10553756(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p23	chr8:0-12800000	1 (0/1/0)
8pter-p22	chr8:0-19200000	1 (0/1/0)
8p23.1	chr8:6300000-12800000	1 (0/0/1)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:10525546..10554166 View in gBrowse