Gene Report

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Basic Info

Approved Symbol	ALG10B
Symbol Alias	KCR1
Approved Name	ALG10B, alpha-1,2-glucosyltransferase
Previous Name	asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)
Name Alias	potassium channel regulator 1, "dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase"
Location	12q12
Position	chr12:38316578-38329728, 1
External Links	HGNC: 31088 Entrez Gene: 144245 Ensembl: ENSG00000175548 UCSC: uc001rln.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Strauss, K. A., 2014	SNP: rs61730283	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0016758	transferase activity, transferring hexosyl groups	molecular function	IEA	2
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	biological process	TAS	4
GO:0043687	post-translational protein modification	biological process	TAS	9
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS	5
GO:0044267	cellular protein metabolic process	biological process	TAS	28

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00510	N-Glycan biosynthesis	3
hsa01030	Glycan structures - biosynthesis 1	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ALG10B	KCNH2	NO	in vivo	14525949

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs61730283	chr12:38321127 - 38321127(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; missense_variant; NMD_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr12:38316578..38329728 View in gBrowse