Gene Report

Basic Info
Approved Symbol SLC6A2
Previous Symbol NET1, NAT1, SLC6A5
Symbol Alias NET
Approved Name solute carrier family 6 (neurotransmitter transporter), member 2
Previous Name solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Name Alias norepinephrine transporter
Location 16q12.2
Position chr16:55655604-55706192, 1
External Links HGNC: 11048
Entrez Gene: 6530
Ensembl: ENSG00000103546
UCSC: uc021tio.1
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Stober, G.,1996 Other variant: SLC6A2_Val69Ile, SLC6A2_Thr99Ile, SLC6A2_Val245Ile, SLC6A2_Val449Ile, SLC6A2_Gly478Ser The results indicated that presence of these variants is not causally related to major psychiatric diseases. Negative Comment on Study
Hadley, D.,1995 Other variant: SLC6A2_TaqI polymorphism No evidence of linkage between manic-depression and the NET gene was found Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 4)

GO terms by database search (count: 15)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 8)

Literature-origin SNPs (count: 2)

LD-proxies (count: 6)

Gene related CNVs (count: 0)

Gene related other variants (count: 6)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 4)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 2)

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Region: chr16:55655604..55706192 View in gBrowse
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