Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ADRA2A
Previous Symbol	ADRA2, ADRA2R
Symbol Alias	ADRAR
Approved Name	adrenoceptor alpha 2A
Previous Name	adrenergic, alpha-2A-, receptor
Name Alias	alpha-2AAR subtype C10, " alpha-2A-adrenergic receptor"
Location	10q25.2
Position	chr10:111077163-111080907, 1
External Links	HGNC: 281 Entrez Gene: 150 Ensembl: ENSG00000150594 UCSC: uc001kzo.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Abou Jamra, R., 2004	Other variant: ADRA2A_-1291C>G	We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 64)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	IDA[10948191]	158
GO:0043235	receptor complex	cellular component	IDA[10948191]	20
GO:0007194	negative regulation of adenylate cyclase activity	biological process	ISS[1354394]	11
GO:0007565	female pregnancy	biological process	IEA	15
GO:0045202	synapse	cellular component	IEA	29
GO:0005886	plasma membrane	cellular component	TAS	360

GO terms by database search (count: 58)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0010700	negative regulation of norepinephrine secretion	biological process	NAS[16531006]; TAS[19477270]	3
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IDA[16531006]; ISS	3
GO:0006260	DNA replication	biological process	IEA	7
GO:0051926	negative regulation of calcium ion transport	biological process	ISS	3
GO:0051379	epinephrine binding	molecular function	IDA[10948191]	2
GO:0007265	Ras protein signal transduction	biological process	TAS[8226727]	7
GO:0007266	Rho protein signal transduction	biological process	TAS[9624180]	4
GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway	biological process	IDA[10948191]	1
GO:0008284	positive regulation of cell proliferation	biological process	TAS[10896916]	44
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0070473	negative regulation of uterine smooth muscle contraction	biological process	IEA	2
GO:0030335	positive regulation of cell migration	biological process	IMP[17655843]	16
GO:0042593	glucose homeostasis	biological process	IMP[10952463]	19
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway	biological process	IDA[10948191]	2
GO:0031696	alpha-2C adrenergic receptor binding	molecular function	IPI[16605244]	1
GO:0032147	activation of protein kinase activity	biological process	IDA[15653687]	4
GO:0032870	cellular response to hormone stimulus	biological process	IGI[10948198]	9
GO:0031692	alpha-1B adrenergic receptor binding	molecular function	ISS	2
GO:0051044	positive regulation of membrane protein ectodomain proteolysis	biological process	IDA[17655843]	5
GO:0046982	protein heterodimerization activity	molecular function	IPI[16605244]; ISS	42
GO:0007596	blood coagulation	biological process	TAS	44
GO:0050995	negative regulation of lipid catabolic process	biological process	IGI[10948198]	6
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	IMP[19965390]	1
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	biological process	IDA[17655843]	1
GO:0005515	protein binding	molecular function	IPI[16531006]	563
GO:0071878	negative regulation of adrenergic receptor signaling pathway	biological process	ISS	1
GO:0051380	norepinephrine binding	molecular function	IDA[2823383]	2
GO:0030036	actin cytoskeleton organization	biological process	TAS[9624180]	9
GO:0007186	G-protein coupled receptor signaling pathway	biological process	ISS[19965390]	64
GO:0050892	intestinal absorption	biological process	TAS[17655843]	1
GO:0032148	activation of protein kinase B activity	biological process	IDA[17215105]	5
GO:0090303	positive regulation of wound healing	biological process	IMP[17655843]	2
GO:0016323	basolateral plasma membrane	cellular component	TAS[17655843]	21
GO:0043406	positive regulation of MAP kinase activity	biological process	IDA[19477270]	6
GO:0045909	positive regulation of vasodilation	biological process	IEA	14
GO:0050796	regulation of insulin secretion	biological process	TAS	24
GO:0071882	phospholipase C-activating adrenergic receptor signaling pathway	biological process	IDA[10948191]	1
GO:0006928	movement of cell or subcellular component	biological process	TAS[9624180]	7
GO:0042596	fear response	biological process	IEA	4
GO:0032811	negative regulation of epinephrine secretion	biological process	NAS[16531006]	4
GO:0045955	negative regulation of calcium ion-dependent exocytosis	biological process	IC[10952463]	2
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	biological process	IDA[17215105]	2
GO:0032795	heterotrimeric G-protein binding	molecular function	IDA[10948191]	1
GO:0004938	alpha2-adrenergic receptor activity	molecular function	IDA[10948191]; ISS[1354394]	2
GO:0001819	positive regulation of cytokine production	biological process	IDA[17655843]	3
GO:0030168	platelet activation	biological process	TAS	22
GO:0002526	acute inflammatory response	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA[19477270]	322
GO:0050955	thermoception	biological process	IEA	1
GO:0019901	protein kinase binding	molecular function	IPI[15653687]	29
GO:0019229	regulation of vasoconstriction	biological process	IEA	10
GO:0046676	negative regulation of insulin secretion	biological process	IMP[10952463]	4
GO:0043268	positive regulation of potassium ion transport	biological process	ISS[1354394]	6
GO:0031996	thioesterase binding	molecular function	IPI[19477270]	2
GO:0007165	signal transduction	biological process	TAS[10896916]	136
GO:0042803	protein homodimerization activity	molecular function	IDA[16605244]	71
GO:0006112	energy reserve metabolic process	biological process	TAS	19
GO:1901020	negative regulation of calcium ion transmembrane transporter activity	biological process	ISS[1354394]	1

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADRA2A	YWHAZ	NO	in vitro;in vivo	10224112
ADRA2A	EIF2B1	NO	in vitro;in vivo	9235896
ADRA2A	ADRB1	NO	in vivo	12529373
ADRA2A	GNAO1	NO	in vitro;in vivo	11732925 , 7887906
ADRA2A	ADRBK1	NO	in vitro;in vivo	7876239
ADRA2A	PRKCD	NO	in vitro	11732925
ADRA2A	GNAI2	YES	in vivo	7887906
ADRA2A	GNAI1	NO	in vitro	11732925

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ADRA2A_-1291C>G	point mutation		1 (0/1/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q25-q26	chr10:104000000-133797422	2 (0/0/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Reference	ID in SZGene	Result Category
17034020	71	Negative
11343863	71	Negative
10696813	71	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

Reference	Description	Category in MDD	Link in MK4MDD
17938633	Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t)	Pos	ADRA2A

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Region: chr10:111077163..111080907 View in gBrowse