Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ADRA2A
Previous Symbol	ADRA2, ADRA2R
Symbol Alias	ADRAR
Approved Name	adrenoceptor alpha 2A
Previous Name	adrenergic, alpha-2A-, receptor
Name Alias	alpha-2AAR subtype C10, " alpha-2A-adrenergic receptor"
Location	10q25.2
Position	chr10:111077163-111080907, 1
External Links	HGNC: 281 Entrez Gene: 150 Ensembl: ENSG00000150594 UCSC: uc001kzo.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Abou Jamra, R., 2004	Other variant: ADRA2A_-1291C>G	We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 64)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	IDA[10948191]	158
GO:0043235	receptor complex	cellular component	IDA[10948191]	20
GO:0007194	negative regulation of adenylate cyclase activity	biological process	ISS[1354394]	11
GO:0007565	female pregnancy	biological process	IEA	15
GO:0045202	synapse	cellular component	IEA	29
GO:0005886	plasma membrane	cellular component	TAS	360

GO terms by database search (count: 58)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0010700	negative regulation of norepinephrine secretion	biological process	NAS[16531006]; TAS[19477270]	3
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IDA[16531006]; ISS	3
GO:0006260	DNA replication	biological process	IEA	7
GO:0051926	negative regulation of calcium ion transport	biological process	ISS	3
GO:0051379	epinephrine binding	molecular function	IDA[10948191]	2
GO:0007265	Ras protein signal transduction	biological process	TAS[8226727]	7
GO:0007266	Rho protein signal transduction	biological process	TAS[9624180]	4
GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway	biological process	IDA[10948191]	1
GO:0008284	positive regulation of cell proliferation	biological process	TAS[10896916]	44
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0070473	negative regulation of uterine smooth muscle contraction	biological process	IEA	2
GO:0030335	positive regulation of cell migration	biological process	IMP[17655843]	16
GO:0042593	glucose homeostasis	biological process	IMP[10952463]	19
GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway	biological process	IDA[10948191]	2
GO:0031696	alpha-2C adrenergic receptor binding	molecular function	IPI[16605244]	1
GO:0032147	activation of protein kinase activity	biological process	IDA[15653687]	4
GO:0032870	cellular response to hormone stimulus	biological process	IGI[10948198]	9
GO:0031692	alpha-1B adrenergic receptor binding	molecular function	ISS	2
GO:0051044	positive regulation of membrane protein ectodomain proteolysis	biological process	IDA[17655843]	5
GO:0046982	protein heterodimerization activity	molecular function	IPI[16605244]; ISS	42
GO:0007596	blood coagulation	biological process	TAS	44
GO:0050995	negative regulation of lipid catabolic process	biological process	IGI[10948198]	6
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	IMP[19965390]	1
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	biological process	IDA[17655843]	1
GO:0005515	protein binding	molecular function	IPI[16531006]	563
GO:0071878	negative regulation of adrenergic receptor signaling pathway	biological process	ISS	1
GO:0051380	norepinephrine binding	molecular function	IDA[2823383]	2
GO:0030036	actin cytoskeleton organization	biological process	TAS[9624180]	9
GO:0007186	G-protein coupled receptor signaling pathway	biological process	ISS[19965390]	64
GO:0050892	intestinal absorption	biological process	TAS[17655843]	1
GO:0032148	activation of protein kinase B activity	biological process	IDA[17215105]	5
GO:0090303	positive regulation of wound healing	biological process	IMP[17655843]	2
GO:0016323	basolateral plasma membrane	cellular component	TAS[17655843]	21
GO:0043406	positive regulation of MAP kinase activity	biological process	IDA[19477270]	6
GO:0045909	positive regulation of vasodilation	biological process	IEA	14
GO:0050796	regulation of insulin secretion	biological process	TAS	24
GO:0071882	phospholipase C-activating adrenergic receptor signaling pathway	biological process	IDA[10948191]	1
GO:0006928	movement of cell or subcellular component	biological process	TAS[9624180]	7
GO:0042596	fear response	biological process	IEA	4
GO:0032811	negative regulation of epinephrine secretion	biological process	NAS[16531006]	4
GO:0045955	negative regulation of calcium ion-dependent exocytosis	biological process	IC[10952463]	2
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	biological process	IDA[17215105]	2
GO:0032795	heterotrimeric G-protein binding	molecular function	IDA[10948191]	1
GO:0004938	alpha2-adrenergic receptor activity	molecular function	IDA[10948191]; ISS[1354394]	2
GO:0001819	positive regulation of cytokine production	biological process	IDA[17655843]	3
GO:0030168	platelet activation	biological process	TAS	22
GO:0002526	acute inflammatory response	biological process	IEA	2
GO:0005737	cytoplasm	cellular component	IDA[19477270]	322
GO:0050955	thermoception	biological process	IEA	1
GO:0019901	protein kinase binding	molecular function	IPI[15653687]	29
GO:0019229	regulation of vasoconstriction	biological process	IEA	10
GO:0046676	negative regulation of insulin secretion	biological process	IMP[10952463]	4
GO:0043268	positive regulation of potassium ion transport	biological process	ISS[1354394]	6
GO:0031996	thioesterase binding	molecular function	IPI[19477270]	2
GO:0007165	signal transduction	biological process	TAS[10896916]	136
GO:0042803	protein homodimerization activity	molecular function	IDA[16605244]	71
GO:0006112	energy reserve metabolic process	biological process	TAS	19
GO:1901020	negative regulation of calcium ion transmembrane transporter activity	biological process	ISS[1354394]	1

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADRA2A	PRKCD	NO	in vitro	11732925
ADRA2A	GNAI1	NO	in vitro	11732925
ADRA2A	GNAI2	YES	in vivo	7887906
ADRA2A	GNAO1	NO	in vitro;in vivo	11732925 , 7887906
ADRA2A	ADRBK1	NO	in vitro;in vivo	7876239
ADRA2A	EIF2B1	NO	in vitro;in vivo	9235896
ADRA2A	YWHAZ	NO	in vitro;in vivo	10224112
ADRA2A	ADRB1	NO	in vivo	12529373

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ADRA2A_-1291C>G	point mutation		1 (0/1/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q25-q26	chr10:104000000-133797422	2 (0/0/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Reference	ID in SZGene	Result Category
17034020	71	Negative
11343863	71	Negative
10696813	71	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

Reference	Description	Category in MDD	Link in MK4MDD
17938633	Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t)	Pos	ADRA2A

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Region: chr10:111077163..111080907 View in gBrowse