Gene Report

Basic Info
Approved Symbol ABCB1
Previous Symbol PGY1, MDR1, CLCS
Symbol Alias P-gp, CD243, GP170, ABC20
Approved Name ATP-binding cassette, sub-family B (MDR/TAP), member 1
Previous Name colchicin sensitivity
Name Alias multidrug resistance protein 1
Location 7q21.12
Position chr7:87503633-87713323, -1
External Links HGNC: 40
Entrez Gene: 5243
Ensembl: ENSG00000085563
UCSC: uc003uiz.2
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Turgut, G.,2009 Other variant: MDR1_exon26_C3435T In conclusion, this is the first study showing association of MDR1 C3435T polymorphism and bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 18)

GO terms by PBA (count: 3)

GO terms by database search (count: 15)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 3)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 3)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 3)

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Region: chr7:87503633..87713323 View in gBrowse
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