Gene Report

Basic Info
Approved Symbol PDE4B
Previous Symbol DPDE4
Approved Name phosphodiesterase 4B, cAMP-specific
Previous Name phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4), "phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)"
Name Alias phosphodiesterase E4 dunce homolog (Drosophila)
Location 1p31
Position chr1:65792514-66374579, 1
External Links HGNC: 8781
Entrez Gene: 5142
Ensembl: ENSG00000184588
UCSC: uc001dco.3
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Xu, W., 2014 SNP: rs538336, rs575056 Other SNPs showing suggestive association included SNPs within known candidate genes for BD, such as PDE4B (p = 7.45×10-5). Negative Comment on Study
McDonald, M. L.,2012 SNP: rs4384209 None of the association tests of the tagSNPs with either BPD I or BPD II reached genome-wide significance (P < 5E-08). Negative Comment on Study
Kahler, A. K., 2010 SNP: rs11208776, rs11208793, rs11208816, rs12080701, rs12140107, rs12142070, rs12731764, rs17424885, rs17452121, rs1937451, rs2144719, rs2186122, rs522037, rs6421482, rs7415930, rs7552762
Haplotype: rs17452121 - rs2186122(AT), rs558325 - rs1040716 - rs11803904 - rs12142015(), rs937605 - rs524897(CT)
nominal associations were found between PDE4B markers and BP in this study Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 23)

GO terms by PBA (count: 3)

GO terms by database search (count: 20)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 140)

Literature-origin SNPs (count: 19)

LD-proxies (count: 121)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 2)

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Region: chr1:65792514..66374579 View in gBrowse
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