Gene Report

Approved Symbol	PDE4B
Previous Symbol	DPDE4
Approved Name	phosphodiesterase 4B, cAMP-specific
Previous Name	phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4), "phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)"
Name Alias	phosphodiesterase E4 dunce homolog (Drosophila)
Location	1p31
Position	chr1:65792514-66374579, 1
External Links	HGNC: 8781 Entrez Gene: 5142 Ensembl: ENSG00000184588 UCSC: uc001dco.3
No. of Studies	3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs538336, rs575056	Other SNPs showing suggestive association included SNPs within known candidate genes for BD, such as PDE4B (p = 7.45×10-5).	Negative	Comment on Study
McDonald, M. L.,2012	SNP: rs4384209	None of the association tests of the tagSNPs with either BPD I or BPD II reached genome-wide significance (P < 5E-08).	Negative	Comment on Study
Kahler, A. K., 2010	SNP: rs11208776, rs11208793, rs11208816, rs12080701, rs12140107, rs12142070, rs12731764, rs17424885, rs17452121, rs1937451, rs2144719, rs2186122, rs522037, rs6421482, rs7415930, rs7552762 Haplotype: rs17452121 - rs2186122(AT), rs558325 - rs1040716 - rs11803904 - rs12142015(), rs937605 - rs524897(CT)	nominal associations were found between PDE4B markers and BP in this study	Positive	Comment on Study

Region: chr1:65792514..66374579 View in gBrowse