Gene Report

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Basic Info

Approved Symbol	TM4SF19
Approved Name	transmembrane 4 L six family member 19
Location	3q29
Position	chr3:196319342-196338503, -1
External Links	HGNC: 25167 Entrez Gene: 116211 Ensembl: ENSG00000145107 UCSC: uc021xjs.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs6785339 Haplotype: rs7639752 - rs6785339(), rs6778879 - rs6785339(G-T), rs6785339 - rs4459932()	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IBA	219

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6785339	chr3:196327568 - 196327568(1)	downstream_gene_variant; missense_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs2270769	chr3:196318023 - 196318023(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs12497601	chr3:196331924 - 196331924(1)	intron_variant; NMD_transcript_variant
rs6777819	chr3:196327989 - 196327989(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs6782336	chr3:196327617 - 196327617(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2280526	chr3:196324532 - 196324532(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Malhotra[2011]_2	chr3:197417247-198249463 (NCBI Build 36 (hg18))	832217	3q29	deletion	De Novo

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:196319342..196338503 View in gBrowse