Gene Report

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Basic Info

Approved Symbol	ST13
Symbol Alias	SNC6, HSPABP1, HIP, P48, FAM10A1
Approved Name	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
Previous Name	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70-interacting protein)
Name Alias	progesterone receptor-associated p48 protein
Location	22q13.2
Position	chr22:40824535-40857022, -1
External Links	HGNC: 11343 Entrez Gene: 6767 Ensembl: ENSG00000100380 UCSC: uc003aze.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Severinsen, J. E., 2006 (a)	SNP: rs1573745, rs710193 Haplotype: rs1573745 - rs710193(), rs1573745 - rs710193 - rs133073(), rs1573745 - rs710193 - rs133073 - rs133070(), rs1573745 - rs710193 - rs133073 - rs133070 - rs133069(), rs710193 - rs133073 (), rs710193 - rs133073 - rs133070(), rs710193 - rs133073 - rs133070 - rs133069 (), rs710193 - rs133073 - rs133070 - rs133069 - rs133068 ()	4-, 5- maker haplotypes spanning GPR24 and ST13 are associated with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030674	protein binding, bridging	molecular function	TAS[8721986]	8
GO:0019904	protein domain specific binding	molecular function	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0032564	dATP binding	molecular function	IEA	1
GO:0032403	protein complex binding	molecular function	IEA	16
GO:0043234	protein complex	cellular component	IEA	27
GO:0005829	cytosol	cellular component	IEA	223
GO:0070389	chaperone cofactor-dependent protein refolding	biological process	IEA	1
GO:0061084	negative regulation of protein refolding	biological process	IEA	1
GO:0051082	unfolded protein binding	molecular function	IEA	6
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0051260	protein homooligomerization	biological process	IEA	13
GO:0042802	identical protein binding	molecular function	IEA	44
GO:0030544	Hsp70 protein binding	molecular function	IEA	3
GO:0006457	protein folding	biological process	TAS[8721986]	7
GO:0051087	chaperone binding	molecular function	IEA	10
GO:0005515	protein binding	molecular function	IPI[21163940]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ST13	F2	NO	in vitro	11687574
ST13	ALB	NO	in vivo	15174051
ST13	OLFM2	NO	yeast 2-hybrid	16169070
ST13	ASF1A	NO	in vitro	15664198
ST13	CXCR2	NO	in vivo	11751889
ST13	SMAD2	NO	yeast 2-hybrid	15231748
ST13	CD101	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 16)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs710193	chr22:40827186 - 40827186(1)	downstream_gene_variant; intron_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(0/1/0)
rs1573745	chr22:40844831 - 40844831(1)	intron_variant; NMD_transcript_variant; splice_region_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs6002181	chr22:40852501 - 40852501(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs5751002	chr22:40854130 - 40854130(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs5758108	chr22:40854435 - 40854435(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs5750995	chr22:40820033 - 40820033(1)	downstream_gene_variant; upstream_gene_variant
rs6002167	chr22:40820742 - 40820742(1)	downstream_gene_variant; upstream_gene_variant
rs6002169	chr22:40821306 - 40821306(1)	downstream_gene_variant; upstream_gene_variant
rs5750998	chr22:40833145 - 40833145(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs739272	chr22:40836590 - 40836590(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs5758104	chr22:40839635 - 40839635(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2266787	chr22:40850948 - 40850948(1)	intron_variant; NMD_transcript_variant
rs5758107	chr22:40852076 - 40852076(1)	intron_variant; NMD_transcript_variant
rs5758093	chr22:40820024 - 40820024(1)	downstream_gene_variant; upstream_gene_variant
rs5758106	chr22:40851239 - 40851239(1)	intron_variant; NMD_transcript_variant
rs6002171	chr22:40827855 - 40827855(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q12.3-13.32	chr22:31800000-49100000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16741940	no significant association was found in this study	Negative

Reference	ID in SZGene	Result Category
16741940	462	Negative

Gene relationship with MDD

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Region: chr22:40824535..40857022 View in gBrowse