Gene Report

Basic Info
Approved Symbol ADRA1A
Previous Symbol ADRA1C
Symbol Alias ADRA1L1
Approved Name adrenoceptor alpha 1A
Previous Name adrenergic, alpha-1A-, receptor
Location 8p21.2
Position chr8:26748150-26867273, -1
External Links HGNC: 277
Entrez Gene: 148
Ensembl: ENSG00000120907
UCSC: uc003xfh.1
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Abou Jamra, R., 2004 Other variant: ADRA1A_492C>T We observed no significant differences in transmissions for any of the genetic variants in the three ADRA genes. Negative Comment on Study
Fallin, M. D.,2005 8 SNP typed, Median D'=0.32, Median r<sup>2</sup> =0.02, 4 LD blocks, 0.33 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 42)

GO terms by PBA (count: 3)

GO terms by database search (count: 39)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 10)

Related other genetic factors
Gene related SNPs (count: 15)

Literature-origin SNPs (count: 3)

LD-proxies (count: 12)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 5)

Gene relationship with MDD

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Region: chr8:26748150..26867273 View in gBrowse
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