Gene Report

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Basic Info

Approved Symbol	OC90
Previous Symbol	PLA2L
Approved Name	otoconin 90
Location	8q24.22
Position	chr8:132024220-132059380, -1
External Links	HGNC: 8100 Entrez Gene: 729330 Ensembl: ENSG00000253117 UCSC: uc011lix.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs7461611	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005509	calcium ion binding	molecular function	IEA	50

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005576	extracellular region	cellular component	IEA	97
GO:0006644	phospholipid metabolic process	biological process	IEA	18
GO:0003674	molecular_function	molecular function	ND	24
GO:0004623	phospholipase A2 activity	molecular function	IEA	3
GO:0005575	cellular_component	cellular component	ND	19
GO:0008150	biological_process	biological process	ND	24
GO:0016042	lipid catabolic process	biological process	IEA	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 13)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7461611	chr8:132036372 - 132036372(1)	intron_variant; splice_region_variant; synonymous_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs7386783	chr8:132041071 - 132041071(1)	missense_variant
rs6992506	chr8:132037563 - 132037563(1)	intron_variant
rs7465349	chr8:132036832 - 132036832(1)	intron_variant
rs7386782	chr8:132041062 - 132041062(1)	missense_variant
rs871960	chr8:132038529 - 132038529(1)	intron_variant
rs7387407	chr8:132034056 - 132034056(1)	intron_variant
rs1995315	chr8:132032929 - 132032929(1)	intron_variant
rs7465374	chr8:132036788 - 132036788(1)	intron_variant
rs7834841	chr8:132034730 - 132034730(1)	intron_variant
rs7840213	chr8:132026910 - 132026910(1)	intron_variant
rs6415547	chr8:132031727 - 132031727(1)	intron_variant
rs6471027	chr8:132031358 - 132031358(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q24.13-q24.3	chr8:121500000-145138636	1 (1/0/0)
8q24.21-qter	chr8:126300000-145138636	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)
8q24	chr8:116700000-145138636	7 (2/2/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:132024220..132059380 View in gBrowse