Gene Report

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Basic Info

Approved Symbol	STX12
Symbol Alias	STX13, STX14
Approved Name	syntaxin 12
Location	1p35.3
Position	chr1:27773183-27824452, 1
External Links	HGNC: 11430 Entrez Gene: 23673 Ensembl: ENSG00000117758 UCSC: uc001bou.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs2064072	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IBA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045121	membrane raft	cellular component	IDA[15469992]	22
GO:0033344	cholesterol efflux	biological process	IDA[15469992]	5
GO:0012505	endomembrane system	cellular component	IBA	9
GO:0000139	Golgi membrane	cellular component	IEA	36
GO:0000149	SNARE binding	molecular function	IBA	7
GO:0048278	vesicle docking	biological process	IBA	1
GO:0006906	vesicle fusion	biological process	IBA	4
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0006886	intracellular protein transport	biological process	IBA	10
GO:0045335	phagocytic vesicle	cellular component	IDA[15469992]	4
GO:0005484	SNAP receptor activity	molecular function	IBA	6
GO:0031083	BLOC-1 complex	cellular component	IDA[19546860]	3
GO:0031201	SNARE complex	cellular component	IDA[19546860]	8
GO:0010008	endosome membrane	cellular component	IEA	17
GO:0005515	protein binding	molecular function	IPI[12191018]	563
GO:0050821	protein stabilization	biological process	IDA[15469992]	12

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04130	SNARE interactions in vesicular transport	7

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
STX12	EPB42	NO	in vitro;in vivo;yeast 2-hybrid	11936273 , 10610180
STX12	PLDN	NO	in vitro;in vivo;yeast 2-hybrid	10610180
STX12	EEA1	NO	in vitro	10458612
STX12	SNAP23	NO	in vitro	9507000
STX12	NAPA	NO	in vitro	9507000 , 9817754
STX12	HOMER1	NO	in vitro;yeast 2-hybrid	10833436

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2064072	chr1:27779722 - 27779722(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs11247684		chr1:27776149 - 27776149(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs11247688		chr1:27795928 - 27795928(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p35-p36	chr1:0-34300000	1 (1/0/0)
1p33-p36	chr1:0-50200000	1 (0/0/1)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:27773183..27824452 View in gBrowse