Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	RTN4
Symbol Alias	NSP-CL, KIAA0886, NOGO, ASY
Approved Name	reticulon 4
Location	2p16.1
Position	chr2:54972187-55112621, -1
External Links	HGNC: 14085 Entrez Gene: 57142 Ensembl: ENSG00000115310 UCSC: uc002rye.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gregorio, S. P.,2005	Other variant: RTN4_3'UTR_CAA insertion	After exhaustively crossing clinical and ethnographical data we failed to demonstrate any association of this Nogo polymorphism with SCZ or BPD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:2000172	regulation of branching morphogenesis of a nerve	biological process	ISS	1
GO:0042995	cell projection	cellular component	IEA	9
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0050770	regulation of axonogenesis	biological process	TAS	7
GO:0005783	endoplasmic reticulum	cellular component	IDA; NAS[11126360]	49
GO:0021801	cerebral cortex radial glia guided migration	biological process	ISS	2
GO:0030334	regulation of cell migration	biological process	IDA[15034570]	9
GO:0030308	negative regulation of cell growth	biological process	IMP[20463223]	11
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0042981	regulation of apoptotic process	biological process	NAS[11126360]	10
GO:0007413	axonal fasciculation	biological process	IBA; ISS	4
GO:0001525	angiogenesis	biological process	IEA	20
GO:0030517	negative regulation of axon extension	biological process	IDA[10667797]	2
GO:0005515	protein binding	molecular function	IPI[11126360]	563
GO:0071786	endoplasmic reticulum tubular network organization	biological process	IMP[18779370]	1
GO:0060317	cardiac epithelial to mesenchymal transition	biological process	IEA	2
GO:0005622	intracellular	cellular component	IMP[14644040]	17
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0005635	nuclear envelope	cellular component	IDA[11126360]	10
GO:0050771	negative regulation of axonogenesis	biological process	TAS	5
GO:0006915	apoptotic process	biological process	NAS[11126360]	39
GO:0030176	integral component of endoplasmic reticulum membrane	cellular component	IDA[10667797]	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 17)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RTN4	PLEKHF2	NO	yeast 2-hybrid	16189514
RTN4	RAB33A	NO	yeast 2-hybrid	16189514
RTN4	COL4A3BP	NO	yeast 2-hybrid	16189514
RTN4	CRMP1	NO	yeast 2-hybrid	16169070
RTN4	UQCRC2	NO	in vitro;in vivo;yeast 2-hybrid	12067236
RTN4	RTN3	NO	in vitro;yeast 2-hybrid	12811824
RTN4	PRR13	NO	yeast 2-hybrid	16169070
RTN4	UQCRC1	NO	in vivo;yeast 2-hybrid	12067236
RTN4	FXR2	NO	yeast 2-hybrid	16189514
RTN4	RTN4IP1	NO	in vivo;yeast 2-hybrid	12067236
RTN4	SPG21	NO	yeast 2-hybrid	16189514
RTN4	LRPAP1	NO	yeast 2-hybrid	16169070
RTN4	CNTNAP1	NO	in vitro;in vivo	14592966
RTN4	TUBA4A	NO	in vivo	12377379
RTN4	LRCH4	NO	yeast 2-hybrid	16189514
RTN4	BCL2L1	NO	in vivo;yeast 2-hybrid	11126360
RTN4	NAPA	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
RTN4_3'UTR_CAA insertion	insertion/deletion	3'UTR	1 (0/1/0)

Gene related regions (count: 7)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2p16.1	chr2:54700000-61000000	1 (0/0/1)
2p16.1-q11.2	chr2:54700000-102100000	1 (1/0/0)
2p16.2-p11.2	chr2:52600000-91800000	1 (1/0/0)
2p13-16	chr2:47500000-71300000	1 (0/0/1)
2p16	chr2:47500000-61000000	1 (0/1/0)
Chr 2	chr2:0-242193529	3 (0/3/0)
2p22.2-p13.3	chr2:36300000-71300000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
15820318	After exhaustively crossing clinical and ethnographical data we failed to demonstrate any association of this Nogo polymorphism with SCZ or BPD.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 7)

Reference	ID in SZGene	Result Category
15661375	5	Negative
15234466	5	Negative
15953657	5	Positive
12425946	5	Positive
15820318	5	Negative
17893707	5	Negative
14741411	5	Negative

Gene relationship with MDD

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Region: chr2:54972187..55112621 View in gBrowse