Gene Report

Basic Info
Approved Symbol CHAT
Approved Name choline O-acetyltransferase
Previous Name choline acetyltransferase
Location 10q11.2
Position chr10:49609095-49665104, 1
External Links HGNC: 1912
Entrez Gene: 1103
Ensembl: ENSG00000070748
UCSC: uc001jhz.2
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Shi, J., 2007 SNP: rs10082479, rs1917810, rs1917813, rs3793791, rs6537546, rs7094248, rs885834 no evidence of interaction among these 19 cholinergic genes was found by Allelic Association, Haploview Tests, FITF analysis and FDR correction Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 21)

GO terms by PBA (count: 2)

GO terms by database search (count: 19)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 29)

Literature-origin SNPs (count: 7)

LD-proxies (count: 22)

Gene related CNVs (count: 1)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr10:49609095..49665104 View in gBrowse
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