Gene Report

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Basic Info

Approved Symbol	SEC63
Symbol Alias	SEC63L, PRO2507, ERdj2, DNAJC23
Approved Name	SEC63 homolog (S. cerevisiae)
Previous Name	SEC63-like (S. cerevisiae)
Location	6q21
Position	chr6:107867756-107958189, -1
External Links	HGNC: 21082 Entrez Gene: 11231 Ensembl: ENSG00000025796 UCSC: uc003psc.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010	SNP: rs2244924	For gene-based test, P-value = 0.018 in STEP1. nominally significant in STEP1 sample, but not survive Bonferroni correction test.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0004872	receptor activity	molecular function	TAS[10799540]	19
GO:0016020	membrane	cellular component	IDA[22375059]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005783	endoplasmic reticulum	cellular component	TAS[10799540]	49
GO:0005515	protein binding	molecular function	IPI[21251912]	563
GO:0031204	posttranslational protein targeting to membrane, translocation	biological process	IEA	1
GO:0001889	liver development	biological process	IEA	14
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	biological process	IMP[22375059]	1
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA	52
GO:0010259	multicellular organismal aging	biological process	IEA	4
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0008565	protein transporter activity	molecular function	IEA	4
GO:0006620	posttranslational protein targeting to membrane	biological process	IMP[22375059]	1
GO:0006807	nitrogen compound metabolic process	biological process	IEA	1
GO:0072001	renal system development	biological process	IEA	1
GO:0006612	protein targeting to membrane	biological process	TAS[10799540]	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SEC63	SEC61B	NO	in vitro	10799540
SEC63	SEC62	NO	in vitro	10799540

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2244924	chr6:107940111 - 107940111(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6q16-q21	chr6:100000000-114200000	1 (0/0/1)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q21	chr6:105000000-114200000	4 (1/2/1)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q21-22	chr6:105000000-130000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:107867756..107958189 View in gBrowse