Gene Report

Basic Info
Approved Symbol GRIN2A
Previous Symbol NMDAR2A
Symbol Alias GluN2A
Approved Name glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Location 16p13.2
Position chr16:9753404-10182754, -1
External Links HGNC: 4585
Entrez Gene: 2903
Ensembl: ENSG00000183454
UCSC: uc002czo.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Itokawa, M.,2003 Other variant: GRIN2A_promoter_(GT)n Our current finding that shows the over transmission of (GT)24 and (GT)25 alleles to affected offspring may support the hypoglutamatergic hypothesis for bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 43)

GO terms by PBA (count: 6)

GO terms by database search (count: 37)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 22)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 4)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr16:9753404..10182754 View in gBrowse
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