Gene Report

Basic Info
Approved Symbol PON1
Previous Symbol PON
Symbol Alias ESA
Approved Name paraoxonase 1
Name Alias esterase A, "arylesterase 1"
Location 7q21.3
Position chr7:95297676-95324707, -1
External Links HGNC: 9204
Entrez Gene: 5444
Ensembl: ENSG00000005421
UCSC: uc003uns.3
No. of Studies 2 (Positive: 2; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kucukali, C. I., 2015 Other variant: PON1_Q192R, PON1_L55M Our findings indicate an association between the genetic variants of PON1 and BD. The PON1 L55M MM genotype seems to be protective against the development of BD. Positive Comment on Study
Ezzaher, A.,2011 SNP: rs662
Other variant: rs854560
In conclusion, our finding reported a significant association between bipolar I disorder and L55M and Q192R of the PON1 gene polymorphisms, suggesting that these polymorphismsmay play a role in the physiopathology of bipolar I disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 26)

GO terms by PBA (count: 1)

GO terms by database search (count: 25)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr7:95297676..95324707 View in gBrowse
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