About us

Our team ( is dedicated to complex disease study with one of the research focuses on development of biological databases by large-scale data integration and data mining. We also develop bioinformatics tools and web servers to facilitate the analysis of genetic, genomic, and epigenomic data of complex diseases. Our published databases include BGI-RIS (2004), SilkDB (2005), ChickVD (2005), IVDB (2007), MethyCancer (2008), MyBASE (2009), ADHD (2012) and MK4MDD (2012). Our published web servers include WEGO (2006), i-GSEA4GWAS (2010) and ICSNPathway (2011).

For the pathway-based analysis (PBA) performed in BDgene, we used a PBA algorithm, named i-GSEA, which was developed by our recent studies and was implemented in our web servers of i-GSEA4GWAS and ICSNPathway.

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1. Guo, L., Zhang, W., Chang, S., Zhang, L., Ott, J. and Wang, J. (2012) MK4MDD: A Multi-Level Knowledge Base and Analysis Platform for Major Depressive Disorder. PLoS ONE, 7, e46335.

2. Zhang, L., Chang, S., Li, Z., Zhang, K., Du, Y., Ott, J. and Wang, J. (2012) ADHDgene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Res, 40, D1003-1009.

3. He, X., Chang, S., Zhang, J., Zhao, Q., Xiang, H., Kusonmano, K., Yang, L., Sun, Z.S., Yang, H. and Wang, J. (2008) MethyCancer: the database of human DNA methylation and cancer. Nucleic Acids Res, 36, D836-841.

4. Zhang, K., Cui, S., Chang, S., Zhang, L. and Wang, J. (2010) i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res, 38 Suppl, W90-95.

5. Zhang, K., Chang, S., Cui, S., Guo, L., Zhang, L. and Wang, J. (2011) ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res, 39 Suppl 2, W437-443.