Gene Report

Basic Info
Approved Symbol MCHR2
Previous Symbol GPR145
Symbol Alias SLT, MCH2, MCH2R
Approved Name melanin-concentrating hormone receptor 2
Previous Name G protein-coupled receptor 145
Location 6q16
Position chr6:99919910-99994247, -1
External Links HGNC: 20867
Entrez Gene: 84539
Ensembl: ENSG00000152034
UCSC: uc003pqi.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Abou Jamra, R., 2010 SNP: rs10872535, rs12214927, rs2397435, rs2397690, rs4642484, rs4840106, rs6913266, rs6925134, rs7746181, rs7754794, rs9376547, rs9376659, rs9385975, rs9385976, rs9399386, rs9484578, rs9496070, rs9496094
Haplotype: rs4642484 - rs9385976 - rs12214927 - rs9376659 - rs9484578 - rs6925134(GTCTAG), rs4642484 - rs9385976 - rs12214927 - rs9376659 - rs9484578 - rs6925134(GTCAAG), rs9496070 - rs7746181 - rs7754794 - rs9496094 - rs2397690(GGGAA), rs9496070 - rs7746181 - rs7754794 - rs9496094 - rs2397690(GAGGG)
MCHR2 is a putative risk factor for BPAD, especially in BPAD male patients with psychotic symptoms. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 4)

GO terms by PBA (count: 2)

GO terms by database search (count: 2)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 46)

Literature-origin SNPs (count: 18)

LD-proxies (count: 28)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr6:99919910..99994247 View in gBrowse
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