Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	MCHR2
Previous Symbol	GPR145
Symbol Alias	SLT, MCH2, MCH2R
Approved Name	melanin-concentrating hormone receptor 2
Previous Name	G protein-coupled receptor 145
Location	6q16
Position	chr6:99919910-99994247, -1
External Links	HGNC: 20867 Entrez Gene: 84539 Ensembl: ENSG00000152034 UCSC: uc003pqi.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Abou Jamra, R., 2010	SNP: rs10872535, rs12214927, rs2397435, rs2397690, rs4642484, rs4840106, rs6913266, rs6925134, rs7746181, rs7754794, rs9376547, rs9376659, rs9385975, rs9385976, rs9399386, rs9484578, rs9496070, rs9496094 Haplotype: rs4642484 - rs9385976 - rs12214927 - rs9376659 - rs9484578 - rs6925134(GTCTAG), rs4642484 - rs9385976 - rs12214927 - rs9376659 - rs9484578 - rs6925134(GTCAAG), rs9496070 - rs7746181 - rs7754794 - rs9496094 - rs2397690(GGGAA), rs9496070 - rs7746181 - rs7754794 - rs9496094 - rs2397690(GAGGG)	MCHR2 is a putative risk factor for BPAD, especially in BPAD male patients with psychotic symptoms.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	TAS	360

GO terms by database search (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004930	G-protein coupled receptor activity	molecular function	IEA	26
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MCHR2	PMCH	YES	in vitro	11416225 , 11404457 , 11274220 , 11478907 , 11839762

Related other genetic factors

Gene related SNPs (count: 46)

Literature-origin SNPs (count: 18)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7754794	chr6:99984779 - 99984779(1)	intron_variant	1(0/1/0)
rs12214927	chr6:100014665 - 100014665(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs4840106	chr6:99955638 - 99955638(1)	intron_variant	1(0/1/0)
rs9496094	chr6:99985234 - 99985234(1)	intron_variant	1(0/1/0)
rs4642484	chr6:100004174 - 100004174(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs2397690	chr6:99995415 - 99995415(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs10872535	chr6:99959928 - 99959928(1)	intron_variant	1(0/1/0)
rs6913266	chr6:99943715 - 99943715(1)	intron_variant	1(0/1/0)
rs9385976	chr6:100009752 - 100009752(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs7746181	chr6:99980662 - 99980662(1)	intron_variant	1(0/1/0)
rs9484578	chr6:100021653 - 100021653(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs9399386	chr6:99999024 - 99999024(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs9376547	chr6:99917848 - 99917848(1)	downstream_gene_variant	1(0/1/0)
rs6925134	chr6:100034140 - 100034140(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs9376659	chr6:100016845 - 100016845(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs2397435	chr6:99940380 - 99940380(1)	intron_variant	1(0/1/0)
rs9496070	chr6:99980153 - 99980153(1)	intron_variant	1(0/1/0)
rs9385975	chr6:100001425 - 100001425(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 28)

rs_ID	Location	Functional Annotation
rs9495922	chr6:99945542 - 99945542(1)	intron_variant
rs4401670	chr6:99962137 - 99962137(1)	intron_variant
rs9376618	chr6:99967676 - 99967676(1)	intron_variant
rs2001456	chr6:99991133 - 99991133(1)	intron_variant; upstream_gene_variant
rs7760129	chr6:99975728 - 99975728(1)	intron_variant
rs7772721	chr6:99918617 - 99918617(1)	downstream_gene_variant
rs9496085	chr6:99982927 - 99982927(1)	intron_variant
rs6925272	chr6:99994392 - 99994392(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs7754726	chr6:99918252 - 99918252(1)	downstream_gene_variant
rs9373294	chr6:99933824 - 99933824(1)	intron_variant
rs11155171	chr6:99949264 - 99949264(1)	intron_variant
rs9496083	chr6:99982714 - 99982714(1)	intron_variant
rs7749425	chr6:99983768 - 99983768(1)	intron_variant
rs4559096	chr6:99943996 - 99943996(1)	intron_variant
rs7749641	chr6:99983945 - 99983945(1)	intron_variant
rs7773011	chr6:99983678 - 99983678(1)	intron_variant
rs12189887	chr6:99959858 - 99959858(1)	intron_variant
rs12215494	chr6:99944656 - 99944656(1)	intron_variant
rs9389934	chr6:99983445 - 99983445(1)	intron_variant
rs9496095	chr6:99985428 - 99985428(1)	intron_variant
rs7748458	chr6:99987656 - 99987656(1)	intron_variant
rs11155195	chr6:99992082 - 99992082(1)	intron_variant; upstream_gene_variant
rs9376634	chr6:99982041 - 99982041(1)	intron_variant
rs4840109	chr6:99981465 - 99981465(1)	intron_variant
rs13212643	chr6:99980437 - 99980437(1)	intron_variant
rs12717189	chr6:99958570 - 99958570(1)	intron_variant
rs9389906	chr6:99959320 - 99959320(1)	intron_variant
rs9403322	chr6:99981751 - 99981751(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q16	chr6:92500000-105000000	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
19502010	833	Positive

Gene relationship with MDD

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Region: chr6:99919910..99994247 View in gBrowse