Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	SLC30A8
Approved Name	solute carrier family 30 (zinc transporter), member 8
Location	8q24.11
Position	chr8:116950273-117176714, 1
External Links	HGNC: 20303 Entrez Gene: 169026 Ensembl: ENSG00000164756 UCSC: uc003yoh.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kajio, Y., 2014	SNP: rs3802177	SNPs in SLC30A8 (rs3802177, Puncorrected=0.042) and HNF4A(rs4812829, Puncorrected=0.0082), which showed the opposite direction of effect.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IDA[15331542]	360

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0070555	response to interleukin-1	biological process	IEA	4
GO:0008270	zinc ion binding	molecular function	IC[15331542]	77
GO:0005794	Golgi apparatus	cellular component	IDA[15331542]	60
GO:0032024	positive regulation of insulin secretion	biological process	ISS	7
GO:0009749	response to glucose	biological process	IMP[16984975]	8
GO:0030141	secretory granule	cellular component	IDA[15331542]	14
GO:0042593	glucose homeostasis	biological process	ISS	19
GO:0071577	zinc II ion transmembrane transport	biological process	IDA[15331542]	2
GO:0034341	response to interferon-gamma	biological process	IEA	2
GO:0006829	zinc II ion transport	biological process	IDA[15331542]	1
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:0006882	cellular zinc ion homeostasis	biological process	ISS	1
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0060627	regulation of vesicle-mediated transport	biological process	ISS	2
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	ISS	16
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0032119	sequestering of zinc ion	biological process	IDA[15331542]	1
GO:0030658	transport vesicle membrane	cellular component	IEA	4
GO:0030073	insulin secretion	biological process	IMP[16984975]	6
GO:0005385	zinc ion transmembrane transporter activity	molecular function	IDA[15331542]	2
GO:0061088	regulation of sequestering of zinc ion	biological process	ISS	1
GO:0030667	secretory granule membrane	cellular component	TAS	4
GO:0042803	protein homodimerization activity	molecular function	ISS	71

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 3)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3802177	chr8:117172786 - 117172786(1)	3_prime_UTR_variant	1(1/0/0)

LD-proxies (count: 2)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs13266634		chr8:117172544 - 117172544(1)	missense_variant
rs11558471		chr8:117173494 - 117173494(1)	3_prime_UTR_variant; downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q24.11	chr8:116700000-118300000	1 (0/0/1)
Chr 8	chr8:0-145138636	3 (0/3/0)
8q24	chr8:116700000-145138636	7 (2/2/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Description	Result Category
24196380	No association was found for SNPs in this gene for SZ.	Negative

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr8:116950273..117176714 View in gBrowse