Reference |
Tested Markers |
Statistical Values/Author Comments |
Result Category |
Comment on Study |
Massat, I.,2002(b) |
Other variant: DRD2_microsatellite |
Our results suggest that the DRD2 microsatellite may be in linkage disequilibrium with a nearby genetic variant involved in the susceptibility to BPAD. |
Positive
|
Comment on Study |
Serretti, A.,2000(a) |
Other variant: DRD2_S311C |
Our results do not show that coding variants of the DRD2 S311C play a major role in conferring susceptibility to major psychoses. |
Negative
|
Comment on Study |
Zou, Y. F.,2010 |
Other variant: DRD2_S311C |
This meta-analysis suggests that mood disorders may not be associated with DRD2 polymorphism, Ser311/Cys311. |
Negative
|
Comment on Study |
Lee, S. Y.,2010 |
SNP: rs1800497 Haplotype: ALDH2_*1/*2 - rs1800497((ALDH2_1*1*)-(DRD2 Taq-I A1/A2)), ALDH2_*1/*2 - rs1800497((ALDH2_1*1*)-(DRD2Taq-I A1/A1)) |
Our findings may provide initial evidence that the ALDH2 and DRD2/ANKK1 genes interact in specific subtypes of bipolar disorders. Our findings also suggest a unique genetic distinction between bipolar I and bipolar II disorders. |
Positive
|
Comment on Study |
Leszczynska-Rodziewicz, A.,2005 |
Other variant: DRD2_141ins/del |
The results suggests that the studied gene variants of type D2 dopamine receptors are not promising candidate genes for bipolar affective illness. |
Negative
|
Comment on Study |
Squassina, A.,2011 |
Other variant: DRD2_TaqIA |
Genotype and allele frequency distributions did not differ significantly between BD patients and controls. |
Negative
|
Comment on Study |
Perez de Castro, I.,1995 |
Other variant: DRD2_(TG)n |
X<sup>2</sup> = 8.93, df = 3, P-value<0.05. The frequencies of the C3 allele of DRD2 gene were significantly higher in patients (0.696) than in controls (0.489) (X<sup>2</sup> = 8.62, df = 1, P-value = 0.029). After multiple correction, the C3 allele p-value = 0.086.
A weak association between DRD2 gene and bipolar affective disorder is suggested |
Positive
|
Comment on Study |
Fallin, M. D.,2005 |
|
5 SNP typed, Median D'=0.95, Median r<sup>2</sup> =0.21, 1 LD blocks, 0.48 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA..
This gene is not suggestive to BP. |
Negative
|
Comment on Study |
Nothen, M. M., 1992 |
Other variant: DRD2_TaqI Polymorphism |
TaqI RFLP for DRD2 : X<sup>2</sup> = 1.05, p-value = 0.30;.
The results of this study do not support the hypothesis that a single mutant form of either the dopamine D1 or the dopamine D2 receptor gene is responsible for the phenotype of all or an appreciable proportion of patients from the general population who are suffering from bipolar affective disorder. |
Negative
|
Comment on Study |
De bruyn, A.,1994 |
Other variant: DRD2_TaqI Polymorphism |
Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions |
Negative
|
Comment on Study |
Mitchell, P.,1992 |
Other variant: DRD2_RFLP |
This study excluded close linkage between the DRDl , DRD2 and bipolar disorder. |
Negative
|
Comment on Study |
Holmes, D.,1990 |
Other variant: DRD2_RFLP |
Mutations at loci in this region are not a common cause of manic depression in the population studied |
Negative
|
Comment on Study |
Huang, C. C.,2012 |
Other variant: DRD2/ANKK1_Taq-IA |
DRD2 Taq-IA A1/A1: logistic Regression P-value=0.18, OR=2.17, 95% CI=0.70-6.77 in BPI, P-value=0.13, OR=2.26, 95% CI=0.79-6.46 in BPII; DRD2 Taq-IA A1/A2: logistic Regression P-value=0.38, OR=0.83, 95% CI=0.34-2.03 in BPI, P-value=0.58, OR=1.24, 95% CI=0.57-2.70 in BPII.
|
Negative
|
Comment on Study |
Savoye, C., 1998 |
Other variant: D2_Taq1 |
Single mutations of either of the studied receptor genes are not major determinants of MDI. |
Negative
|
Comment on Study |
Wang, T. Y., 2013 |
SNP: rs1800497 |
We provide preliminary evidence for a gender-specific effect of the SLC6A4 and DRD2 gene variants for the risk of BP-I and of BP-II. We also found gender-specific interaction between 5-HTTLPR and DRD2 Taq-IA polymorphisms in patients with bipolar disorder. |
Positive
|
Comment on Study |
Wang, Y. S., 2013 |
|
a significant interaction of the DRD2 Taq-I A1/A1 and the ALDH2*1*1 genotypes in BP-II without AD was revealed compared with normal controls |
Positive
|
Comment on Study |
Szczepankiewicz, A., 2007 |
Other variant: DRD2_-151ins/del |
We have not found any significant differences in genotype distribution of the polymorphisms of this dopamine gene between bipolar disorder patients with/without comorbid alcohol abuse and controls. |
Negative
|
Comment on Study |
Hu, M. C.,2012 |
Other variant: DRD2_TaqI Polymorphism |
The MAOA-uVNTR 3-repeat had a significant protective effect on the ALC+BP (odds ratio=0.432, p=0.035) but not on the healthy controls. However, the interaction between the MAOA-uVNTR 3-repeat and DRD2 A1/A2 was a risk factor in the ALC+BP (odds ratio=3.451, p=0.018). CONCLUSIONS: We indicated the impact of the association between MAOA-uVNTR 3-repeat and DRD2 A1/A2 with ALC+BP. |
Positive
|
Comment on Study |
Furlong, R. A., 1998 (b) |
Other variant: DRD2_-141CIns/Del |
These results do not support a major role for the DRD2 gene in the etiology of either bipolar or unipolar affective disorders. |
Negative
|
Comment on Study |
Stober, G., 1998 |
Other variant: DRD2_5'flanking_-141C Ins/Del |
Our findings indicate that the 2141C Del variant in the 59 flanking region of the human dopamine D2 receptor gene is unlikely to play a substantial role in genetic predisposition to major psychiatric disorders in Caucasians. |
Negative
|
Comment on Study |
Manki, H.,1996 |
Other variant: DRD2_S311C |
Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. |
Negative
|
Comment on Study |
Li, T.,1999 |
Other variant: DRD2_141ins/del, DRD2_TaqIA, DRD2_S311C |
We found association between a functional DRD2 promoter variant (P = 0.03 by allele) and the DRD2 taq1A polymorphism (P = 0.001 by allele) in Chinese bipolar disorder patients. |
Positive
|
Comment on Study |
Souery, D.,1996(b) |
Other variant: DRD2_(CA)n |
Association and linkage disequilibrium were excluded between bipolar affective disorder and these four candidate genes in our sample. |
Negative
|
Comment on Study |
Sasaki, T.,1996 |
Other variant: DRD2_S311C |
Our results do not provide evidence for an association between this D2 receptor variant and schizophrenia, or delusional disorder, or bipolar affective disorder. |
Negative
|
Comment on Study |
Hamshere, M. L.,2012 |
Other variant: DRD2_TaqIA |
The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP-II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP-II disorder and that BP-I and BP-II are genetically distinct. |
Positive
|
Comment on Study |
Serretti, A.,2000(b) |
Other variant: DRD2_polymorphism |
The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample. |
Negative
|
Comment on Study |
Kirov, G.,1999(a) |
Other variant: DRD2_141ins/del |
No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied. |
Negative
|
Comment on Study |
Bocchetta, A.,1999 |
Other variant: DRD2_intron 1_(TG)n |
Using TDT, no significant differences were found with regard to DRD2 polymorphism. |
Negative
|
Comment on Study |