Gene Report

Basic Info
Approved Symbol NOS3
Symbol Alias ECNOS, eNOS
Approved Name nitric oxide synthase 3 (endothelial cell)
Name Alias endothelial nitric oxide synthase
Location 7q36
Position chr7:150990995-151014588, 1
External Links HGNC: 7876
Entrez Gene: 4846
Ensembl: ENSG00000164867
UCSC: uc003wif.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kittel-Schneider, S., 2014 SNP: rs2070744, rs1799983
Other variant: NOS3_Intron 4 VNTR_4a/b
None of the investigated polymorphisms in this gene was associated with BD. Negative Comment on Study
Reif, A., 2006 (b) Haplotype: NOS3_T-786C - NOS3_Intron4_VNTR - NOS3_G894T(c-a-g), NOS3_T-786C - NOS3_Intron4_VNTR - NOS3_G894T(c-a-t), NOS3_T-786C - NOS3_Intron4_VNTR - NOS3_G894T(c-b-g), NOS3_T-786C - NOS3_Intron4_VNTR - NOS3_G894T(c-b-t), NOS3_T-786C - NOS3_Intron4_VNTR - NOS3_G894T(c-c-t), NOS3_T-786C - NOS3_Intron4_VNTR - NOS3_G894T(t-a-g), NOS3_T-786C - NOS3_Intron4_VNTR - NOS3_G894T(t-b-g), NOS3_T-786C - NOS3_Intron4_VNTR - NOS3_G894T(t-b-t)
Other variant: NOS3_G894T, NOS3_Intron4_VNTR, NOS3_T-786C
Our results thus suggest that the NOS-III genotype may convey a modest genetic risk to develop bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 59)

GO terms by PBA (count: 3)

GO terms by database search (count: 56)

Gene related KEGG pathways (count: 5)

KEGG pathways by PBA (count: 3)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 5)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 4)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr7:150990995..151014588 View in gBrowse
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