Gene Report

Basic Info
Approved Symbol TPP1
Previous Symbol CLN2, SCAR7
Approved Name tripeptidyl peptidase I
Previous Name ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease), "spinocerebellar ataxia, autosomal recessive 7"
Name Alias TPP I
Location 11p15.4
Position chr11:6612763-6619461, -1
External Links HGNC: 2073
Entrez Gene: 1200
Ensembl: ENSG00000166340
UCSC: uc001mel.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Ament, S. A., 2015 P-value=0.0057. No individual gene had a significant burden of segregating rare variants in BD pedigrees after correcting for multiple tests, although several genes had suggestive trends. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 26)

GO terms by PBA (count: 3)

GO terms by database search (count: 23)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:6612763..6619461 View in gBrowse
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