Gene Report

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Basic Info

Approved Symbol	DYNC1I1
Previous Symbol	DNCI1
Symbol Alias	DNCIC1
Approved Name	dynein, cytoplasmic 1, intermediate chain 1
Previous Name	dynein, cytoplasmic, intermediate polypeptide 1
Location	7q21.3
Position	chr7:95772506-96110322, 1
External Links	HGNC: 2963 Entrez Gene: 1780 Ensembl: ENSG00000158560 UCSC: uc003uoc.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs319331	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003774	motor activity	molecular function	TAS[10049579]	2

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS	50
GO:0000776	kinetochore	cellular component	IDA[19229290]	7
GO:0000777	condensed chromosome kinetochore	cellular component	IEA	7
GO:0008152	metabolic process	biological process	IEA; ISS; TAS[10049579]	50
GO:0047496	vesicle transport along microtubule	biological process	IMP[24561039]; ISS	5
GO:0008017	microtubule binding	molecular function	ISS	10
GO:0036464	cytoplasmic ribonucleoprotein granule	cellular component	IDA[15121898]	3
GO:0005868	cytoplasmic dynein complex	cellular component	ISS	3
GO:0031982	vesicle	cellular component	IDA[20682791]	20
GO:0055037	recycling endosome	cellular component	IDA[24561039]	14
GO:0005874	microtubule	cellular component	IEA	24
GO:0003777	microtubule motor activity	molecular function	ISS	8
GO:0000922	spindle pole	cellular component	IDA[19229290]	6
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	biological process	TAS	4
GO:0005829	cytosol	cellular component	TAS	223
GO:0005515	protein binding	molecular function	IPI[14985359]	563
GO:0030507	spectrin binding	molecular function	IDA[23704327]	4

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DYNC1I1	BICD1	NO	in vivo	17139249
DYNC1I1	DYNLRB1	YES	yeast 2-hybrid	16189514
DYNC1I1	DYNLL1	NO	in vitro	11148209
DYNC1I1	DYNLT1	NO	in vitro	8943288
DYNC1I1	STAU1	NO	in vitro	15121898
DYNC1I1	DYNLL2	NO	yeast 2-hybrid	16189514

Related other genetic factors

Gene related SNPs (count: 8)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs319331	chr7:95915051 - 95915051(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs319327	chr7:95920788 - 95920788(1)	intron_variant; non_coding_transcript_variant
rs319328	chr7:95920400 - 95920400(1)	intron_variant; non_coding_transcript_variant
rs319333	chr7:95914312 - 95914312(1)	intron_variant; non_coding_transcript_variant
rs319300	chr7:95903007 - 95903007(1)	intron_variant; non_coding_transcript_variant
rs319325	chr7:95922802 - 95922802(1)	intron_variant; non_coding_transcript_variant
rs6465485	chr7:95887257 - 95887257(1)	intron_variant; non_coding_transcript_variant
rs10237844	chr7:95897588 - 95897588(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21	chr7:77900000-98400000	4 (0/2/2)
7q21.3	chr7:93300000-98400000	1 (0/1/0)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
21912391	genes significantly affected in female MDD subjects	Pos	DYNC1I1

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Region: chr7:95772506..96110322 View in gBrowse