Gene Report

Basic Info
Approved Symbol SLC6A5
Previous Symbol NET1
Symbol Alias GLYT2
Approved Name solute carrier family 6 (neurotransmitter transporter), member 5
Previous Name solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Name Alias glycine transporter 2
Location 11p15.1
Position chr11:20599400-20659285, 1
External Links HGNC: 11051
Entrez Gene: 9152
Ensembl: ENSG00000165970
UCSC: uc001mqd.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Jamra, R. A., 2006 (b) SNP: rs1805091, rs2000959, rs2241940, rs2289683
Other variant: SLC6A5_AC-tandem-repeat
Our results do not suggest that a common genetic variant at the GLYT2 locus contributes to BPAD and/or schizophrenia in patients of German descent. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 10)

GO terms by PBA (count: 3)

GO terms by database search (count: 7)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 17)

Literature-origin SNPs (count: 4)

LD-proxies (count: 13)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr11:20599400..20659285 View in gBrowse
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