Gene Report

Basic Info
Approved Symbol GRIK2
Previous Symbol GLUR6
Symbol Alias GluK2, MRT6
Approved Name glutamate receptor, ionotropic, kainate 2
Location 6q16.3
Position chr6:101398788-102070083, 1
External Links HGNC: 4580
Entrez Gene: 2898
Ensembl: ENSG00000164418
UCSC: uc003pqp.4
No. of Studies 3 (Positive: 1; Negative: 1; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Ament, S. A., 2015 P-value=0.011. No individual gene had a significant burden of segregating rare variants in BD pedigrees after correcting for multiple tests, although several genes had suggestive trends. Positive Comment on Study
McQuillin, A.,2011 Gene related CNV occurred in two or more cases but not in controls. Trend Comment on Study
Xu, W., 2014 SNP: rs2852571 SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as GRIK2 (p=4.18×10-5). Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 39)

GO terms by PBA (count: 7)

GO terms by database search (count: 32)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 14)

Related other genetic factors
Gene related SNPs (count: 5)

Literature-origin SNPs (count: 1)

LD-proxies (count: 4)

Gene related CNVs (count: 2)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

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Region: chr6:101398788..102070083 View in gBrowse
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