Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	DYNC1H1
Previous Symbol	DNECL, DNCL, DNCH1
Symbol Alias	Dnchc1, HL-3, p22, DHC1
Approved Name	dynein, cytoplasmic 1, heavy chain 1
Previous Name	dynein, cytoplasmic, heavy polypeptide 1
Location	14q32.31
Position	chr14:101964528-102050792, 1
External Links	HGNC: 2961 Entrez Gene: 1778 Ensembl: ENSG00000197102 UCSC: uc001yks.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gonzalez, S., 2014	SNP: rs4900525 Other variant: DYNC1H1_Chr14:101530331, DYNC1H1_Chr14:101533297	The associated SNP in this gene showed no significant association with BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005829	cytosol	cellular component	TAS	223
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	biological process	TAS	4
GO:0034063	stress granule assembly	biological process	ISS	1
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0005515	protein binding	molecular function	IPI[17043677]	563
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0005524	ATP binding	molecular function	IEA	118
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS	15
GO:0006810	transport	biological process	IEA	47
GO:0033962	cytoplasmic mRNA processing body assembly	biological process	ISS	2
GO:0008152	metabolic process	biological process	IEA	50
GO:0007018	microtubule-based movement	biological process	IEA	7
GO:0051293	establishment of spindle localization	biological process	IMP[23027904]	1
GO:0005813	centrosome	cellular component	IDA[21399614]	34
GO:0003777	microtubule motor activity	molecular function	IEA	8
GO:0007052	mitotic spindle organization	biological process	NAS[8227145]	1
GO:0051959	dynein light intermediate chain binding	molecular function	IEA	1
GO:0016887	ATPase activity	molecular function	IEA	13
GO:0006996	organelle organization	biological process	TAS	23
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0030175	filopodium	cellular component	IEA	5
GO:0005868	cytoplasmic dynein complex	cellular component	NAS[8666668]	3
GO:0005874	microtubule	cellular component	IDA[21525035]	24

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DYNC1H1	SMAD2	NO	yeast 2-hybrid	15231748
DYNC1H1	NDEL1	NO	in vitro;in vivo	11163259
DYNC1H1	YWHAG	NO	in vivo	15324660
DYNC1H1	DYNLL1	NO	in vitro	14760703

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4900525	chr14:101938404 - 101938404(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
DYNC1H1_Chr14:101530331		Exonic	1 (0/0/1)
DYNC1H1_Chr14:101533297		Exonic	1 (0/0/1)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr14:101964528..102050792 View in gBrowse